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    CHEK2 checkpoint kinase 2 [ Lagopus leucura (white-tailed ptarmigan) ]

    Gene ID: 122176925, updated on 22-Mar-2024

    Summary

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    Gene symbol
    CHEK2
    Gene description
    checkpoint kinase 2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Lagopus leucura
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Tetraoninae; Lagopus
    Orthologs
    human mouse all
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    Genomic context

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    See CHEK2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    100 current USGS_WTPT01 (GCF_019238085.1) Unplaced Scaffold NW_024962260.1 (2143887..2156957)

    NW_024962260.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 2, facilitated glucose transporter member 11-like Neighboring gene coiled-coil domain containing 117 Neighboring gene uncharacterized LOC122176926 Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene phosphatidylinositol transfer protein beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_024962260 Unplaced Scaffold Reference USGS_WTPT01

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Chk2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Lagopus leucura Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference USGS_WTPT01

    Genomic

    1. NW_024962260.1 Reference USGS_WTPT01

      Range
      2143887..2156957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042865909.1 → XP_042721843.1  serine/threonine-protein kinase Chk2 isoform X1

      Conserved Domains (2) summary
      cd00060
      Location:88 → 179
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:190 → 463
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    2. XM_042865910.1 → XP_042721844.1  serine/threonine-protein kinase Chk2 isoform X2

      Conserved Domains (1) summary
      cd14084
      Location:64 → 337
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
    Nucleotide Protein
    Heading Accession and Version

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