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    fliC flagellar biosynthesis; flagellin [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

    Gene ID: 1253480, updated on 6-Oct-2023

    Summary

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    Gene symbol
    fliC
    Gene description
    flagellar biosynthesis; flagellin
    Locus tag
    STM1959
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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    Genomic context

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    Sequence:
    NC_003197.2 (2047655..2049154, complement)

    NC_003197.2Genomic Context describing neighboring genes Neighboring gene transposase for IS200 Neighboring gene N-methylation of lysine residues in flagellin Neighboring gene filament capping protein Neighboring gene repressor of class 3a and 3b operons (RflA activity) Neighboring gene putative export chaperone for FliD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003197.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages. Gram AM, et al. J Immunol, 2021 Feb 1. PMID 33380493, Free PMC Article
    2. A structure-function study of C-terminal residues predicted to line the export channel in Salmonella Flagellin. Burtchett T, et al. Biochim Biophys Acta Gen Subj, 2021 Jan. PMID 32980501
    3. FliC's Hypervariable D3 Domain Is Required for Robust Anti-Flagellin Primary Antibody Responses. López-Yglesias AH, et al. Immunohorizons, 2019 Sep 5. PMID 31488506, Free PMC Article
    4. Hybrid flagellin as a T cell independent vaccine scaffold. Bennett KM, et al. BMC Biotechnol, 2015 Aug 12. PMID 26265529, Free PMC Article
    5. Structural basis for stabilization of the hypervariable D3 domain of Salmonella flagellin upon filament formation. Muskotál A, et al. J Mol Biol, 2010 Nov 5. PMID 20868693

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages.
      Title: Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages.
    2. Structural and Functional Comparison of Salmonella Flagellar Filaments Composed of FljB and FliC.
      Title: Structural and Functional Comparison of Salmonella Flagellar Filaments Composed of FljB and FliC.
    3. Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages.
      Title: Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages.
    4. A structure-function study of C-terminal residues predicted to line the export channel in Salmonella Flagellin.
      Title: A structure-function study of C-terminal residues predicted to line the export channel in Salmonella Flagellin.
    5. this study shows that FliC's hypervariable D3 domain Is required for robust anti-flagellin primary antibody responses
      Title: FliC's Hypervariable D3 Domain Is Required for Robust Anti-Flagellin Primary Antibody Responses.
    6. Our results provide proof-of-principle demonstration that a reengineered hybrid FliC could be used as a platform for polymeric subunit vaccines, enhancing T cell-dependent and possibly inducing T-independent antibody responses from B-1 B cells as well.
      Title: Hybrid flagellin as a T cell independent vaccine scaffold.
    7. Data indicate the biological activity of a TLR5:flagellin complex with a 2:2 stoichiometry.
      Title: Determination of the physiological 2:2 TLR5:flagellin activation stoichiometry revealed by the activity of a fusion receptor.
    8. the NAIP5-NLRC4 inflammasome is induced by direct interactions with conserved N- and C-terminal regions of flagellin
      Title: Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.
    9. These findings established the signaling pathway mediating the chemokine induction activity of LL-37 in primary keratinocytes and the synergistic effect of LL-37 on the cell response to flagellin.
      Title: Signaling pathways mediating chemokine induction in keratinocytes by cathelicidin LL-37 and flagellin.
    10. A flagellin mutant deprived of the complete D3 domain (DeltaD3_FliC) exhibited a significantly decreased thermal stability (T(m) 41.9 degrees C) as compared to intact flagellin (T(m) 47.3 degrees C).
      Title: Structural basis for stabilization of the hypervariable D3 domain of Salmonella flagellin upon filament formation.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    General gene information

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    regulatory

    • Loc: c2049154-2049149 regulatory_class = ribosome_binding_site

    General protein information

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    Preferred Names
    flagellar biosynthesis; flagellin
    NP_460912.1
    • filament structural protein; flagellin (phase-1-I flagellin). (SW:FLIC_SALTY)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003197.2 Reference assembly

      Range
      2047655..2049154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_460912.1 flagellar biosynthesis; flagellin [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

      See identical proteins and their annotated locations for NP_460912.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5W8MDM6, A0A5X6MHX9, A0A622BWX3, A0A628PC47, A0A710UIB0, A0A748PFJ9, Q6V2T2
      Conserved Domains (1) summary
      PRK08026
      Location:1 → 495
      PRK08026; FliC/FljB family flagellin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06179.4

    Gene LinkOut

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