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    LOC127270958 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182112694-182113362 [ Homo sapiens (human) ]

    Gene ID: 127270958, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC127270958
    Gene description
    H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182112694-182113362
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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    Genomic context

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    See LOC127270958 in Genome Data Viewer
    Location:
    chromosome: 1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (182143559..182144227)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (181500213..181500881)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182112694..182113362)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182025348-182025878 Neighboring gene zinc finger protein 648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2196 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:182070081-182070851 Neighboring gene uncharacterized LOC105371642 Neighboring gene Sharpr-MPRA regulatory region 10342 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:182112509-182112685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182113363-182114030 Neighboring gene YPEL5 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1344 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:182199023-182199595 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:182218347-182218848 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:182231616-182231824 Neighboring gene FOXA motif-containing MPRA enhancer 10/11 Neighboring gene Sharpr-MPRA regulatory region 4291 Neighboring gene NANOG hESC enhancer GRCh37_chr1:182270844-182271361 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1617

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_092810.1 

      Range
      101..769
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      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      182143559..182144227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      181500213..181500881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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