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    Crip1 cysteine-rich protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 12925, updated on 27-Nov-2024

    Summary

    Official Symbol
    Crip1provided by MGI
    Official Full Name
    cysteine-rich protein 1provided by MGI
    Primary source
    MGI:MGI:88501
    See related
    Ensembl:ENSMUSG00000006360 AllianceGenome:MGI:88501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRHP; CRP1; Crip
    Summary
    Predicted to enable peptide binding activity and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to UV-B; intrinsic apoptotic signaling pathway in response to DNA damage; and response to zinc ion. Predicted to be located in cytoplasm. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; integumental system; and limb segment. Orthologous to human CRIP1 (cysteine rich protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 3684.4), small intestine adult (RPKM 2998.6) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Crip1 in Genome Data Viewer
    Location:
    12 F1; 12 61.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113115632..113117499)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113152012..113153879)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cysteine rich protein 2 Neighboring gene predicted gene, 30599 Neighboring gene tubulin epsilon and delta complex 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114406329-114406556 Neighboring gene origin of replication downstream of immunoglobulin heavy chain (Igh) locus Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114425816-114425969 Neighboring gene transmembrane protein 121

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV-B ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cellular response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to antibiotic ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to zinc ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    cysteine-rich protein 1
    Names
    CRP-1
    cysteine-rich intestinal protein
    cysteine-rich protein 1 (intestinal)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007763.3NP_031789.1  cysteine-rich protein 1

      See identical proteins and their annotated locations for NP_031789.1

      Status: VALIDATED

      Source sequence(s)
      AK008269, BX511593, DT908028
      Consensus CDS
      CCDS26205.1
      UniProtKB/Swiss-Prot
      P04006, P63254, Q3THF0
      UniProtKB/TrEMBL
      Q6P3B4, Q8C2N7
      Related
      ENSMUSP00000006523.8, ENSMUST00000006523.12
      Conserved Domains (1) summary
      cd09478
      Location:457
      LIM_CRIP; The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      113115632..113117499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)