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    LOC129662116 ReSE screen-validated silencer GRCh37_chr7:127438882-127439229 [ Homo sapiens (human) ]

    Gene ID: 129662116, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC129662116
    Gene description
    ReSE screen-validated silencer GRCh37_chr7:127438882-127439229
    Gene type
    biological region
    Feature type(s)
    regulatory: silencer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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    Genomic context

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    See LOC129662116 in Genome Data Viewer
    Location:
    chromosome: 7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (127798828..127799175)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (129110520..129110867)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127438882..127439229)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene PAX4 5' regulatory region Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127291844-127292462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26588 Neighboring gene paired box 4 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:127305706-127306528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26589 Neighboring gene SND1 divergent transcript Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:127343327-127343826 Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:127366923-127367714 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:127375481-127375695 Neighboring gene CD2 cytoplasmic tail binding protein 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18596 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:127540623-127541156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26590 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:127583497-127583998 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:127583999-127584498 Neighboring gene MPRA-validated peak6714 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26592 Neighboring gene SND1 intronic transcript 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_159152.1 

      Range
      101..448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      127798828..127799175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      129110520..129110867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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