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    LOC129663685 ReSE screen-validated silencer GRCh37_chr15:90544586-90544754 [ Homo sapiens (human) ]

    Gene ID: 129663685, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC129663685
    Gene description
    ReSE screen-validated silencer GRCh37_chr15:90544586-90544754
    Gene type
    biological region
    Feature type(s)
    regulatory: silencer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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    Genomic context

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    See LOC129663685 in Genome Data Viewer
    Location:
    chromosome: 15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90001354..90001522)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (87757358..87757526)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90544586..90544754)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ARPIN-AP3S2 readthrough Neighboring gene RNA, U7 small nuclear 111 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90452345-90452529 Neighboring gene actin related protein 2/3 complex inhibitor Neighboring gene zinc finger and SCAN domain containing 5A pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:90525469-90526190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6807 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90545369-90546137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90546138-90546905 Neighboring gene zinc finger protein 710 Neighboring gene microRNA 3174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90581285-90581804 Neighboring gene Sharpr-MPRA regulatory region 12348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90585951-90586930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90597371-90598254 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90602135-90602846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6809 Neighboring gene ZNF710 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_160691.1 

      Range
      101..269
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      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      90001354..90001522
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      87757358..87757526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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