Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp1b1provided by MGI
Official Full Name: cytochrome P450, family 1, subfamily b, polypeptide 1provided by MGI
Primary source: MGI:MGI:88590
See related: Ensembl:ENSMUSG00000024087 AllianceGenome:MGI:88590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CP1B; CYPIB1; P4501b1
Summary: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including camera-type eye development; regulation of gene expression; and retinoid metabolic process. Acts upstream of or within several processes, including blood vessel endothelial cell migration; endothelial cell-cell adhesion; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 41.8), spleen adult (RPKM 11.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E3; 17 50.3 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (80014369..80022490, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (79706940..79715061, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose.
Title: Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose.
CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.
Title: CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.
AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors.
Title: AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors.
ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression.
Title: ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression.
Cytochrome P450 1B1 Expression Regulates Intracellular Iron Levels and Oxidative Stress in the Retinal Endothelium.
Title: Cytochrome P450 1B1 Expression Regulates Intracellular Iron Levels and Oxidative Stress in the Retinal Endothelium.
6beta-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice.
Title: 6β-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice.
Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension.
Title: Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension.
Study determined changes in the transcriptome profiles of Cyp1b1+/+ and Cyp1b1-/- retinal astrocytes (AC) by RNA sequencing and identified 585 differentially expressed genes. Results of the first report of RNA-seq investigation of the retinal AC transcriptome and the molecular pathways impacted by Cyp1b1 expression demonstrated an important role for Cyp1b1 expression in the regulation of various retinal AC functions.
Title: Retinal astrocytes transcriptome reveals Cyp1b1 regulates the expression of genes involved in cell adhesion and migration.
Ultraviolet A (UVA) induced oxidative stress, DNA damage, and estrogen-DNA adducts in mouse corneal endothelium (CE) recapitulates Fuchs endothelial corneal dystrophy (FECD). Results identified involvement of CYP1B1, the key estrogen-metabolizing enzyme, in sex-dependent differences in CE susceptibility to UVA and detected greater mtDNA damage and estrogen-DNA adduct formation in more severely affected female mice.
Title: Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.
Cyp1b1-/- suppresses genes supported by Srebp. Gestational vitamin A deficiency (dietary retinal defiiency during pregnancy) effects distinguish Srebp1 and Srebp2 mediation. Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver.
Title: Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U03283 (e-PCR)
- UniSTS:186115

Cyp1b1 (e-PCR), detects polymorphism
- UniSTS:525894

Cyp1b1 (e-PCR), detects polymorphism
- UniSTS:525895

Cyp1b1 (e-PCR), detects polymorphism
- UniSTS:468828

Cyp1b1 (e-PCR), detects polymorphism
- UniSTS:462981

Cyp1b1 (e-PCR), detects polymorphism
- UniSTS:546715

NoName (e-PCR)
- UniSTS:224724

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA modification	IEA Inferred from Electronic Annotation more info
involved_in DNA modification	ISO Inferred from Sequence Orthology more info
involved_in adrenal gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within benzene-containing compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within benzene-containing compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in benzene-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cortisol stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to luteinizing hormone stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to progesterone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in cellular response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within dibenzo-p-dioxin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrogen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrous cycle	IEA Inferred from Electronic Annotation more info
involved_in ganglion development	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in membrane lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to 3-methylcholanthrene	IEA Inferred from Electronic Annotation more info
involved_in response to arsenic-containing substance	IEA Inferred from Electronic Annotation more info
involved_in response to dexamethasone	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to follicle-stimulating hormone	IEA Inferred from Electronic Annotation more info
involved_in response to indole-3-methanol	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina vasculature development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within toxin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trabecular meshwork development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cytochrome P450 1B1

Names: cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450CMEF; cytochrome P450EF; hydroperoxy icosatetraenoate dehydratase

NP_001351818.1

EC 1.14.14.1

EC 4.2.1.152

NP_034124.1

EC 1.14.14.1

EC 4.2.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.