Dbx1 developing brain homeobox 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dbx1provided by MGI
Official Full Name: developing brain homeobox 1provided by MGI
Primary source: MGI:MGI:94867
See related: Ensembl:ENSMUSG00000030507 AllianceGenome:MGI:94867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dbx
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within regulation of transcription by RNA polymerase II and ventral spinal cord interneuron specification. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; future brain; head mesenchyme; urogenital ridge; and vertebral axis musculature. Orthologous to human DBX1 (developing brain homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 19.0), CNS E14 (RPKM 4.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B4; 7 31.44 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (49281247..49286583, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (49631499..49636835, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diversity within olfactory sensory derivatives revealed by the contribution of Dbx1 lineages.
Title: Diversity within olfactory sensory derivatives revealed by the contribution of Dbx1 lineages.
The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2delta transcriptional cascade.
Title: The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade.
Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling.
Title: Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling.
Transcriptomes of electrophysiologically recorded Dbx1-derived respiratory neurons of the preBotzinger complex in neonatal mice.
Title: Transcriptomes of electrophysiologically recorded Dbx1-derived respiratory neurons of the preBötzinger complex in neonatal mice.
Specific contribution of neurons from the Dbx1 lineage to the piriform cortex.
Title: Specific contribution of neurons from the Dbx1 lineage to the piriform cortex.
Foxg1 Directly Represses Dbx1 to Confine the POA and Subsequently Regulate Ventral Telencephalic Patterning.
Title: Foxg1 Directly Represses Dbx1 to Confine the POA and Subsequently Regulate Ventral Telencephalic Patterning.
Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex.
Title: Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex.
Study finds that Dbx1 interneurons govern the frequency and precise timing of breaths in awake adult mice with sensorimotor feedback intact, Dbx1 preBotC neurons constitute an essential core component of the inspiratory oscillator, knowledge directly relevant to human health and physiology.
Title: Dbx1 Pre-Bötzinger Complex Interneurons Comprise the Core Inspiratory Oscillator for Breathing in Unanesthetized Adult Mice.
Here, the authors show that the telencephalic preoptic area is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal medial subnucleus of the amygdala inhibitory neuronal subtype identity.
Title: Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues.
Study defines a fate map of the hypothalamus with respect to Developing Brain Homeobox 1 (Dbx1) expression in hypothalamic progenitor zones. In a temporally regulated manner, Dbx1-derived neurons contribute to molecularly distinct neuronal populations in the hypothalamus that have been implicated in a variety of hypothalamic-driven behaviors
Title: Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dbx1 (e-PCR), detects polymorphism
- UniSTS:525896

MGI:3841781 (e-PCR)
- UniSTS:525897

AI426026 (e-PCR)
- UniSTS:165528

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation in spinal cord	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein DBX1

Names: Mmox C; developing brain homeobox protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.