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    Dcpp1 demilune cell and parotid protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 13184, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dcpp1provided by MGI
    Official Full Name
    demilune cell and parotid protein 1provided by MGI
    Primary source
    MGI:MGI:105949
    See related
    Ensembl:ENSMUSG00000096445 AllianceGenome:MGI:105949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p20; Dcpp; Dcpp-1
    Summary
    Acts upstream of or within blastocyst development. Located in extracellular space. Is expressed in several structures, including blastocyst; early embryo; lymph node; oviduct; and submandibular gland primordium. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Dcpp1 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.11 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24099643..24101827)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23880669..23882853)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine protease 32 Neighboring gene serine protease 21 Neighboring gene STARR-seq mESC enhancer starr_42066 Neighboring gene predicted gene, 50058 Neighboring gene demilune cell and parotid protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning, sequencing and in situ localization of a transcript specific to both sublingual demilune cells and parotid intercalated duct cells in mouse salivary glands. Bekhor I, et al. Arch Oral Biol, 1994 Dec. PMID 7717881
    2. Demilune cell and parotid protein from murine oviductal epithelium stimulates preimplantation embryo development. Lee KF, et al. Endocrinology, 2006 Jan. PMID 16239302
    3. DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer. Song H, et al. Biochem Biophys Res Commun, 2017 Dec 2. PMID 28988106
    4. Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice". Wang Y, et al. Sci Transl Med, 2023 May 17. PMID 37196063
    5. Identification of a human ortholog of the mouse Dcpp gene locus, encoding a novel member of the CSP-1/Dcpp salivary protein family. Mullins JJ, et al. Physiol Genomics, 2006 Dec 13. PMID 16954406

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comment on "Inflammasome inhibition prevents alpha-synuclein pathology and dopaminergic neurodegeneration in mice".
      Title: Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice".
    2. Mouse DCPP1 exerted its function on pancreatic cancer cells by activating intracellular signaling pathways involved in aggressive cancer phenotype of human pancreatic cancer cells. The objective of this study was to evaluate the potential of DCPP1 as a putative mouse ortholog of human PAUF by sequence alignment and functional studies.
      Title: DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer.
    3. Dcpp is highly expressed in the oviductal lumen in the presence of preimplantation embryos.
      Title: Demilune cell and parotid protein from murine oviductal epithelium stimulates preimplantation embryo development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11676, MGC102440

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    demilune cell and parotid protein
    Names
    common salivary protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410030.1 → NP_001396959.1  demilune cell and parotid protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC110262
      UniProtKB/TrEMBL
      L7N1X9

    2. NM_019910.3 → NP_064294.2  demilune cell and parotid protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC110262
      Consensus CDS
      CCDS37478.1
      UniProtKB/TrEMBL
      L7N1X9, Q99JV1
      Related
      ENSMUSP00000064663.4, ENSMUST00000068580.4
      Conserved Domains (1) summary
      cl03205
      Location:28 → 158
      Jacalin_like; Jacalin-like lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24099643..24101827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317222.2 → XP_017172711.1  demilune cell and parotid protein isoform X1

      UniProtKB/TrEMBL
      Q99JV1
      Conserved Domains (1) summary
      cl03205
      Location:53 → 183
      Jacalin_like; Jacalin-like lectin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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