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    Drp2 dystrophin related protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 13497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Drp2provided by MGI
    Official Full Name
    dystrophin related protein 2provided by MGI
    Primary source
    MGI:MGI:107432
    See related
    Ensembl:ENSMUSG00000000223 AllianceGenome:MGI:107432
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DRP-2
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in synapse organization and synaptic signaling. Located in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human DRP2 (dystrophin related protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 10.1), cortex adult (RPKM 10.1) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Drp2 in Genome Data Viewer
    Location:
    X E3; X 56.18 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133304868..133357323)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134404124..134456574)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene transmembrane protein 35A Neighboring gene centromere protein I Neighboring gene STARR-seq mESC enhancer starr_47958 Neighboring gene STARR-seq mESC enhancer starr_47959 Neighboring gene TATA-box binding protein associated factor 7 like Neighboring gene STAT3-interacting protein as a repressor pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of DRP2, a novel human dystrophin homologue. Roberts RG, et al. Nat Genet, 1996 Jun. PMID 8640231
    2. Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth. Sherman DL, et al. J Neurosci, 2012 Jul 4. PMID 22764250, Free PMC Article
    3. Expression of the dystrophin-related protein 2 (Drp2) transcript in the mouse. Dixon AK, et al. J Mol Biol, 1997 Jul 25. PMID 9245586
    4. Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy. Sherman DL, et al. Neuron, 2001 Jun. PMID 11430802
    5. gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins. Alessi A, et al. Exp Cell Res, 2006 Oct 1. PMID 16857187

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cajal band appositions contain a dystroglycan complex that includes periaxin and dystrophin-related protein (Drp)2.
      Title: Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159048, MGC159050

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dystrophin-related protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411867.1 → NP_001398796.1  dystrophin-related protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672064
      UniProtKB/TrEMBL
      Q3TZ53

    2. NM_001411868.1 → NP_001398797.1  dystrophin-related protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672064
      UniProtKB/TrEMBL
      B1AV35, Q3TZ53
      Related
      ENSMUSP00000108850.3, ENSMUST00000113224.9

    3. NM_001411869.1 → NP_001398798.1  dystrophin-related protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672064
      UniProtKB/Swiss-Prot
      Q05AA6, Q61095, Q8C4R1
      UniProtKB/TrEMBL
      Q3TZ53

    4. NM_001411870.1 → NP_001398799.1  dystrophin-related protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672064
      UniProtKB/Swiss-Prot
      Q05AA6, Q61095, Q8C4R1
      UniProtKB/TrEMBL
      Q3TZ53

    5. NM_001411871.1 → NP_001398800.1  dystrophin-related protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672064
      UniProtKB/TrEMBL
      Q3TZ53

    6. NM_001411872.1 → NP_001398801.1  dystrophin-related protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672064
      UniProtKB/Swiss-Prot
      Q05AA6, Q61095, Q8C4R1
      UniProtKB/TrEMBL
      Q3TZ53

    7. NM_010078.4 → NP_034208.2  dystrophin-related protein 2 isoform 3

      See identical proteins and their annotated locations for NP_034208.2

      Status: VALIDATED

      Source sequence(s)
      AL672064
      Consensus CDS
      CCDS30394.1
      UniProtKB/Swiss-Prot
      Q05AA6, Q61095, Q8C4R1
      UniProtKB/TrEMBL
      Q3TZ53
      Related
      ENSMUSP00000115246.2, ENSMUST00000153424.8
      Conserved Domains (4) summary
      cd00176
      Location:111 → 339
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:357 → 385
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:608 → 656
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:422 → 583
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      133304868..133357323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251218.2 → XP_030107078.1  dystrophin-related protein 2 isoform X5

      UniProtKB/TrEMBL
      Q3TZ53
      Conserved Domains (4) summary
      cd00176
      Location:84 → 194
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:209 → 237
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:460 → 508
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:274 → 435
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    2. XM_036161807.1 → XP_036017700.1  dystrophin-related protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q05AA6, Q61095, Q8C4R1
      UniProtKB/TrEMBL
      Q3TZ53
      Related
      ENSMUSP00000108854.2, ENSMUST00000113228.8
      Conserved Domains (4) summary
      cd00176
      Location:111 → 339
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:357 → 385
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:608 → 656
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:422 → 583
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    3. XM_011247730.1 → XP_011246032.1  dystrophin-related protein 2 isoform X1

      UniProtKB/TrEMBL
      Q3TZ53
      Conserved Domains (4) summary
      cd00176
      Location:33 → 261
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:279 → 307
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:515 → 563
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:344 → 490
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    4. XM_030251220.1 → XP_030107080.1  dystrophin-related protein 2 isoform X5

      UniProtKB/TrEMBL
      Q3TZ53
      Conserved Domains (4) summary
      cd00176
      Location:84 → 194
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:209 → 237
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:460 → 508
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:274 → 435
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    RNA

    1. XR_003952997.2 RNA Sequence

    2. XR_001782733.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05AA6.1 GenPept UniProtKB/Swiss-Prot:Q05AA6

    Gene LinkOut

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