Epha2 Eph receptor A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epha2provided by MGI
Official Full Name: Eph receptor A2provided by MGI
Primary source: MGI:MGI:95278
See related: Ensembl:ENSMUSG00000006445 AllianceGenome:MGI:95278
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eck; Myk2; Sek2; Sek-2
Summary: Predicted to enable growth factor binding activity; molecular function activator activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including lens fiber cell morphogenesis; mammary gland epithelium development; and osteoclast differentiation. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; endometrium; and limb. Used to study cataract 6 multiple types. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EPHA2 (EPH receptor A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 25.3), small intestine adult (RPKM 22.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 73.67 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (141028532..141056695)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (141301221..141329384)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long non-coding RNA MALAT1 protects against Abeta1-42 induced toxicity by regulating the expression of receptor tyrosine kinase EPHA2 via quenching miR-200a/26a/26b in Alzheimer's disease.
Title: Long non-coding RNA MALAT1 protects against Aβ(1-42) induced toxicity by regulating the expression of receptor tyrosine kinase EPHA2 via quenching miR-200a/26a/26b in Alzheimer's disease.
Exosomal EphA2 promotes tumor metastasis of triple-negative breast cancer by damaging endothelial barrier.
Title: Exosomal EphA2 promotes tumor metastasis of triple-negative breast cancer by damaging endothelial barrier.
EphA2 recognizes Dermatophagoidespteronyssinus to mediate airway inflammation in asthma.
Title: EphA2 recognizes Dermatophagoidespteronyssinus to mediate airway inflammation in asthma.
EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas.
Title: EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas.
Mutation of the EPHA2 Tyrosine-Kinase Domain Dysregulates Cell Pattern Formation and Cytoskeletal Gene Expression in the Lens.
Title: Mutation of the EPHA2 Tyrosine-Kinase Domain Dysregulates Cell Pattern Formation and Cytoskeletal Gene Expression in the Lens.
Genotype, Age, Genetic Background, and Sex Influence Epha2-Related Cataract Development in Mice.
Title: Genotype, Age, Genetic Background, and Sex Influence Epha2-Related Cataract Development in Mice.
EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2.
Title: EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2.
Phosphorylation of PLCgamma1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer.
Title: Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer.
Expression and functional analyses of ephrin type-A receptor 2 in mouse spermatogonial stem cellsdagger.
Title: Expression and functional analyses of ephrin type-A receptor 2 in mouse spermatogonial stem cells†.
EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells.
Title: EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Gene trapped (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Epha2 (e-PCR), detects polymorphism
- UniSTS:495880

NoName (e-PCR)
- UniSTS:548478

X78339 (e-PCR)
- UniSTS:125853

AW545284 (e-PCR)
- UniSTS:179113

Epha2 (e-PCR), detects polymorphism
- UniSTS:502742

Epha2 (e-PCR), detects polymorphism
- UniSTS:527333

Epha2 (e-PCR), detects polymorphism
- UniSTS:266985

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axial mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in branching involved in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cAMP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in lens fiber cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mammary gland epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within notochord formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pericyte cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to growth factor	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
located_in leading edge membrane	ISO Inferred from Sequence Orthology more info
located_in leading edge membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in tight junction	IEA Inferred from Electronic Annotation more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ephrin type-A receptor 2

Names: epithelial cell kinase; tyrosine-protein kinase receptor ECK; tyrosine-protein kinase receptor MPK-5; tyrosine-protein kinase receptor SEK-2

NP_034269.2

EC 2.7.10.1

XP_006538591.1

EC 2.7.10.1

XP_036019541.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010139.3 → NP_034269.2 ephrin type-A receptor 2 precursor

See identical proteins and their annotated locations for NP_034269.2

Status: VALIDATED

Source sequence(s)

AK144202, AW457468, CJ088701

Consensus CDS

CCDS18869.1

UniProtKB/Swiss-Prot

Q03145, Q3UNI2, Q60633, Q62212

Related

ENSMUSP00000006614.3, ENSMUST00000006614.3

Conserved Domains (8) summary

cd09543
Location:903 → 972

SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors

smart00454
Location:903 → 969

SAM; Sterile alpha motif

cd10480
Location:27 → 200

EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2

cd00063
Location:440 → 527

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:331 → 425

fn3; Fibronectin type III domain

pfam07714
Location:618 → 872

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:579 → 609

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl21453
Location:608 → 876

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

141028532..141056695

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163648.1 → XP_036019541.1 ephrin type-A receptor 2 isoform X1

Conserved Domains (4) summary

cd09543
Location:655 → 724

SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors

pfam00041
Location:191 → 272

fn3; Fibronectin type III domain

pfam14575
Location:322 → 363

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl21453
Location:360 → 628

PKc_like; Protein Kinases, catalytic domain
XM_006538528.5 → XP_006538591.1 ephrin type-A receptor 2 isoform X2

Conserved Domains (4) summary

cd09543
Location:629 → 698

SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors

pfam00041
Location:165 → 243

fn3; Fibronectin type III domain

pfam14575
Location:298 → 335

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl21453
Location:334 → 602

PKc_like; Protein Kinases, catalytic domain