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    Lgr5 leucine rich repeat containing G protein coupled receptor 5 [ Mus musculus (house mouse) ]

    Gene ID: 14160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lgr5provided by MGI
    Official Full Name
    leucine rich repeat containing G protein coupled receptor 5provided by MGI
    Primary source
    MGI:MGI:1341817
    See related
    Ensembl:ENSMUSG00000020140 AllianceGenome:MGI:1341817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FEX; Gpr49
    Summary
    The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in frontal lobe adult (RPKM 8.3), limb E14.5 (RPKM 3.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lgr5 in Genome Data Viewer
    Location:
    10 D2; 10 63.51 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115286219..115423685, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115450314..115587780, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1128 Neighboring gene predicted gene, 53633 Neighboring gene THAP domain containing, apoptosis associated protein 2 Neighboring gene zinc finger, C3H1-type containing Neighboring gene STARR-positive B cell enhancer mm9_chr10:114916114-114916415 Neighboring gene STARR-seq mESC enhancer starr_27944 Neighboring gene RIKEN cDNA A930009A15 gene Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_27945 Neighboring gene STARR-seq mESC enhancer starr_27946 Neighboring gene STARR-seq mESC enhancer starr_27947 Neighboring gene RIKEN cDNA 4930422I22 gene Neighboring gene tetraspanin 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice. Guo Q, et al. Am J Transl Res, 2019. PMID 31497199, Free PMC Article
    2. Distinct Levels of Radioresistance in Lgr5(+) Colonic Epithelial Stem Cells versus Lgr5(+) Small Intestinal Stem Cells. Hua G, et al. Cancer Res, 2017 Apr 15. PMID 28202528, Free PMC Article
    3. Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status. Peck BC, et al. J Biol Chem, 2017 Feb 17. PMID 28053090, Free PMC Article
    4. Lgr5-overexpressing mesenchymal stem cells augment fracture healing through regulation of Wnt/ERK signaling pathways and mitochondrial dynamics. Lin W, et al. FASEB J, 2019 Jul. PMID 30991839
    5. Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. Shi F, et al. J Neurosci, 2012 Jul 11. PMID 22787049, Free PMC Article

    See all (728) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cells.
      Title: Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cells.
    2. Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.
      Title: Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.
    3. Study on Lgr5 expression in pancreas tissues and organoids by lineage tracing.
      Title: Study on Lgr5 expression in pancreas tissues and organoids by lineage tracing.
    4. ANKRD22 Drives Rapid Proliferation of Lgr5(+) Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury.
      Title: ANKRD22 Drives Rapid Proliferation of Lgr5(+) Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury.
    5. IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
      Title: IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
    6. PTEN-mediated AKT/beta-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes.
      Title: PTEN-mediated AKT/β-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes.
    7. Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation.
      Title: Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation.
    8. alphaSMA(+) fibroblasts suppress Lgr5(+) cancer stem cells and restrain colorectal cancer progression.
      Title: αSMA(+) fibroblasts suppress Lgr5(+) cancer stem cells and restrain colorectal cancer progression.
    9. Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease.
      Title: Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease.
    10. Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.
      Title: Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.
    Submit: New GeneRIF Correction See all GeneRIFs (92)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epithelial cell proliferation involved in renal tubule morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hair follicle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within inner ear development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within oocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing G-protein coupled receptor 5
    Names
    G protein-coupled receptor 49
    follicle expressed hormone
    orphan G-protein coupled receptor FEX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010195.2 → NP_034325.2  leucine-rich repeat-containing G-protein coupled receptor 5 precursor

      See identical proteins and their annotated locations for NP_034325.2

      Status: REVIEWED

      Source sequence(s)
      AK132387, BM935530
      Consensus CDS
      CCDS24180.1
      UniProtKB/Swiss-Prot
      Q3V1L2, Q9Z1P4
      UniProtKB/TrEMBL
      G3UXX4
      Related
      ENSMUSP00000020350.9, ENSMUST00000020350.15
      Conserved Domains (6) summary
      smart00013
      Location:33 → 70
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:88 → 386
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:354 → 375
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:68 → 91
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:575 → 820
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13855
      Location:92 → 150
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      115286219..115423685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1P4.2 GenPept UniProtKB/Swiss-Prot:Q9Z1P4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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