Fkbp4 FK506 binding protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fkbp4provided by MGI
Official Full Name: FK506 binding protein 4provided by MGI
Primary source: MGI:MGI:95543
See related: Ensembl:ENSMUSG00000030357 AllianceGenome:MGI:95543
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p59; FKBP-4; FKBP52; FKPB52; FKBP-52
Summary: Enables several functions, including heat shock protein binding activity; nuclear glucocorticoid receptor binding activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within several processes, including androgen receptor signaling pathway; embryo implantation; and steroid hormone receptor complex assembly. Located in nucleus. Is expressed in epithelium of penile urethra; genital tubercle mesenchyme of male; pancreas epithelium; and prepuce of male. Used to study androgen insensitivity syndrome. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 152.7), testis adult (RPKM 150.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 63.0 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128407066..128415619, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128430103..128438656, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies.
Title: Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies.
Differential Effects of Fkbp4 and Fkbp5 on Regulation of the Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells.
Title: Differential Effects of Fkbp4 and Fkbp5 on Regulation of the Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells.
Study demonstrates that FKBP52 by itself does not directly affect cognition and may play an indirect, modulatory role in the functional pathology of Alzheimer's disease, whereas it directly affects motor coordination, an early sign of neurodegenerative damages to the brain.
Title: A novel role for the immunophilin FKBP52 in motor coordination.
identify a novel steroid-responsive FKBP52-dependent pathway suppressing the expression and activity of tryptophan-2,3-dioxygenase
Title: Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.
study identifies Fkbp4 and Fkbp5 as novel components of the Ago2 RISC loading complex
Title: The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly.
FKBP52 is not involved in all branches of GR signaling, but rather acts in a gene-specific manner to regulate GR transcriptional activation.
Title: Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice.
FKBP52 regulates androgen receptor function through the BF3 surface.
Title: Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
Findings suggest that Fkbp52 deficiency diminishes the threshold against OS by reducing PRDX6 levels.
Title: Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress.
Fkbp52 is an important molecular regulator in the androgen-mediated pathway of urethra morphogenesis.
Title: Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis.
Data propose a model in which FKBP52 loss reduces GR control of gluconeogenesis, predisposing the liver to steatosis under HF-diet conditions attributable to a shunting of metabolism from glucose production to lipogenesis.
Title: Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW208983 (e-PCR)
- UniSTS:179470

NoName (e-PCR)
- UniSTS:235561

RH125352 (e-PCR)
- UniSTS:162174

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables copper-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables copper-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in copper ion transport	IEA Inferred from Electronic Annotation more info
involved_in copper ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization or depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein-containing complex localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reproductive structure development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within steroid hormone receptor complex assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP4

Names: 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FKBP59; HBI; HSP-binding immunophilin; PPIase FKBP4; immunophilin FKBP52; rotamase

NP_034349.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010219.4 → NP_034349.1 peptidyl-prolyl cis-trans isomerase FKBP4

See identical proteins and their annotated locations for NP_034349.1

Status: VALIDATED

Source sequence(s)

AK083912, BY280598, X17069

Consensus CDS

CCDS20573.1

UniProtKB/Swiss-Prot

P30416, Q3TVC9

Related

ENSMUSP00000032508.5, ENSMUST00000032508.11

Conserved Domains (4) summary

sd00006
Location:274 → 301

TPR; TPR repeat [structural motif]

pfam00254
Location:43 → 134

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam00515
Location:321 → 352

TPR_1; Tetratricopeptide repeat

pfam13414
Location:322 → 384

TPR_11; TPR repeat