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    Gdf3 growth differentiation factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 14562, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gdf3provided by MGI
    Official Full Name
    growth differentiation factor 3provided by MGI
    Primary source
    MGI:MGI:95686
    See related
    Ensembl:ENSMUSG00000030117 AllianceGenome:MGI:95686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vgr2; Gdf-3; Vgr-2; ecat9
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is important in embryogenesis and likely plays a role ocular and skeletal development. Mice lacking a functional copy of this gene exhibit defects in early embryonic development resulting in embryonic lethality. [provided by RefSeq, Aug 2016]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Gdf3 in Genome Data Viewer
    Location:
    6 F1; 6 57.7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122582362..122587046, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122605403..122610087, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_17230 Neighboring gene STARR-positive B cell enhancer ABC_E9101 Neighboring gene STARR-positive B cell enhancer ABC_E8128 Neighboring gene STARR-seq mESC enhancer starr_17234 Neighboring gene STARR-positive B cell enhancer mm9_chr6:122565848-122566149 Neighboring gene Dppa3 promoter region Neighboring gene developmental pluripotency-associated 3 Neighboring gene STARR-seq mESC enhancer starr_17237 Neighboring gene predicted gene, 57756

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC123990, MGC123991

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within endoderm development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within formation of anatomical boundary IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within notochord development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within primitive streak formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within somite rostral/caudal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    growth/differentiation factor 3
    Names
    VG-1-related protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008108.5NP_032134.2  growth/differentiation factor 3 preproprotein

      See identical proteins and their annotated locations for NP_032134.2

      Status: REVIEWED

      Source sequence(s)
      AC158651, AK152457
      Consensus CDS
      CCDS20499.1
      UniProtKB/Swiss-Prot
      Q07104, Q3TUX1
      UniProtKB/TrEMBL
      Q3ZB19
      Related
      ENSMUSP00000032211.5, ENSMUST00000032211.5
      Conserved Domains (2) summary
      smart00204
      Location:266366
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:110204
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      122582362..122587046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505540.3XP_006505603.1  growth/differentiation factor 3 isoform X1

      Conserved Domains (1) summary
      cl40434
      Location:142242
      TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily