U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    E7 transforming protein [ Human papillomavirus 5 ]

    Gene ID: 1489048, updated on 18-Aug-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    E7
    Gene description
    transforming protein
    Locus tag
    HpV5gp2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human papillomavirus 5
    Lineage
    Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; Firstpapillomavirinae; Betapapillomavirus
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_001531.1 (663..974)

    NC_001531.1Genomic Context describing neighboring genes Neighboring gene transforming protein Neighboring gene replication protein Neighboring gene regulatory protein Neighboring gene E4 Neighboring gene E5 Neighboring gene minor capsid protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001531.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cutaneous human papillomavirus E7 type-specific effects on differentiation and proliferation of organotypic skin cultures. Westphal K, et al. Cell Oncol, 2009. PMID 19478389, Free PMC Article
    2. BetaHPV E6 and E7 colocalize with NuMa in dividing keratinocytes. Oswald E, et al. Virus Genes, 2019 Oct. PMID 31290065
    3. A humanized mouse model of HPV-associated pathology driven by E7 expression. Buitrago-Pérez Á, et al. PLoS One, 2012. PMID 22911850, Free PMC Article
    4. Nucleotide sequence and genome organization of human papillomavirus type 5. Zachow KR, et al. Virology, 1987 May. PMID 3033892
    5. Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase. Neveu G, et al. Methods, 2012 Dec. PMID 22898364, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors show an interaction of Human papillomaviruses 5 and 8 oncoproteins E6 and E7 with the nuclear mitotic apparatus protein 1 (NuMA).
      Title: BetaHPV E6 and E7 colocalize with NuMa in dividing keratinocytes.
    2. The E7 protein of cutaneous beta HPV5 binds pRb and promotes its degradation.
      Title: A humanized mouse model of HPV-associated pathology driven by E7 expression.
    3. Expression of E7 from HPV 5 can overcome p16(INK4a) induced cell cycle arrest in a subset of keratinocytes.
      Title: Cutaneous human papillomavirus E7 type-specific effects on differentiation and proliferation of organotypic skin cultures.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    transforming protein
    NP_041366.1
    • putative

    VOG classification

    Description:

    • VOGd0001 [R] Transforming protein E7
    • Regulation of Cellular Metabolism

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001531.1 Reference assembly

      Range
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_041366.1 transforming protein [Human papillomavirus 5]

      See identical proteins and their annotated locations for NP_041366.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P06932, P26559, Q6LBH5, Q6YNY3, Q81963, Q81987
      UniProtKB/TrEMBL
      Q76WJ6, R9QBR6
      Conserved Domains (1) summary
      pfam00527
      Location:3 → 94
      E7; E7 protein, Early protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06932.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials