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    Cfap20 cilia and flagella associated protein 20 [ Mus musculus (house mouse) ]

    Gene ID: 14894, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cfap20provided by MGI
    Official Full Name
    cilia and flagella associated protein 20provided by MGI
    Primary source
    MGI:MGI:107428
    See related
    Ensembl:ENSMUSG00000031796 AllianceGenome:MGI:107428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtl3; T10-2A2; 2600014O15Rik
    Summary
    Involved in flagellated sperm motility. Located in cilium. Is active in axonemal B tubule inner sheath and sperm flagellum. Is expressed in several structures, including alimentary system; blastocyst; hemolymphoid system gland; olfactory epithelium; and retina nuclear layer. Orthologous to human CFAP20 (cilia and flagella associated protein 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 41.9), testis adult (RPKM 40.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cfap20 in Genome Data Viewer
    Location:
    8 C5; 8 47.12 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96146867..96161716, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95420249..95434869, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8259 Neighboring gene zinc finger protein 319 Neighboring gene U6 snRNA biogenesis 1 Neighboring gene matrix metallopeptidase 15 Neighboring gene VISTA enhancer mm71 Neighboring gene STARR-positive B cell enhancer ABC_E245 Neighboring gene casein kinase 2, alpha prime polypeptide Neighboring gene STARR-seq mESC enhancer starr_22388 Neighboring gene RIKEN cDNA 4933406B17 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rapid mapping of genomic P1 clones: the mouse L-isoaspartyl/D-aspartyl methyltransferase gene. MacLaren DC, et al. Genomics, 1996 Jul 15. PMID 8661142
    2. Sequence and expression pattern of an evolutionarily conserved transcript identified by gene trapping. Rijkers T, et al. Biochim Biophys Acta, 1996 Jul 17. PMID 8688464
    3. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article
    4. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Chen Z, et al. Cell, 2023 Nov 9. PMID 37865089, Free PMC Article
    5. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyglutamylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cilium beat frequency involved in ciliary motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cilium beat frequency involved in ciliary motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cilium beat frequency involved in ciliary motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal B tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 20
    Names
    UPF0468 protein C16orf80 homolog
    gene trap locus 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008187.2 → NP_032213.2  cilia- and flagella-associated protein 20

      See identical proteins and their annotated locations for NP_032213.2

      Status: VALIDATED

      Source sequence(s)
      BC119023, BM934726, CB195345
      Consensus CDS
      CCDS40445.1
      UniProtKB/Swiss-Prot
      P70212, Q3T9D6, Q8BTU1
      Related
      ENSMUSP00000034249.7, ENSMUST00000034249.8
      Conserved Domains (1) summary
      pfam05018
      Location:1 → 185
      DUF667; Protein of unknown function (DUF667)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96146867..96161716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153763.1 → XP_036009656.1  cilia- and flagella-associated protein 20 isoform X2

      UniProtKB/Swiss-Prot
      P70212, Q3T9D6, Q8BTU1
      Conserved Domains (1) summary
      pfam05018
      Location:1 → 185
      DUF667; Protein of unknown function (DUF667)

    2. XM_036153762.1 → XP_036009655.1  cilia- and flagella-associated protein 20 isoform X1

      Conserved Domains (1) summary
      pfam05018
      Location:142 → 272
      DUF667; Protein of unknown function (DUF667)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTU1.1 GenPept UniProtKB/Swiss-Prot:Q8BTU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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