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    ACA1_131220 Poly(ADPribose) polymerase catalytic domain containing protein [ Acanthamoeba castellanii str. Neff ]

    Gene ID: 14914721, updated on 18-Sep-2024

    Summary

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    Gene symbol
    ACA1_131220
    Gene description
    Poly(ADPribose) polymerase catalytic domain containing protein
    Locus tag
    ACA1_131220
    See related
    AmoebaDB:ACA1_131220; VEuPathDB:ACA1_131220
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Acanthamoeba castellanii str. Neff (strain: Neff, culture-collection: ATCC:30010)
    Lineage
    Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida; Acanthamoebidae; Acanthamoeba
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    Genomic context

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    See ACA1_131220 in Genome Data Viewer
    Location:
    chromosome: Unknown
    Exon count:
    39

    NW_004457346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene oxidoreductase molybdopterin binding domain containing protein Neighboring gene ribosomal protein S32, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004457346.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Clarke M, et al. Genome Biol, 2013 Feb 1. PMID 23375108, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Poly(ADPribose) polymerase catalytic domain containing protein
    XP_004336154.1
    • encoded by transcript ACA1_131220A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NW_004457346.1 Reference assembly

      Range
      21931..33340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004336106.1 → XP_004336154.1  Poly(ADPribose) polymerase catalytic domain containing protein [Acanthamoeba castellanii str. Neff]

      See identical proteins and their annotated locations for XP_004336154.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      L8GPV8
      Conserved Domains (7) summary
      cd07997
      Location:2011 → 2110
      WGR_PARP; WGR domain of poly(ADP-ribose) polymerases
      cd00204
      Location:1351 → 1491
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01437
      Location:2153 → 2550
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam12796
      Location:753 → 878
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:782 → 835
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:1646 → 1701
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:750 → 779
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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