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    H19 H19, imprinted maternally expressed transcript [ Mus musculus (house mouse) ]

    Gene ID: 14955, updated on 2-Nov-2024

    Summary

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    Official Symbol
    H19provided by MGI
    Official Full Name
    H19, imprinted maternally expressed transcriptprovided by MGI
    Primary source
    MGI:MGI:95891
    See related
    Ensembl:ENSMUSG00000000031 AllianceGenome:MGI:95891
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EyeLinc6
    Summary
    Acts upstream of or within negative regulation of cell population proliferation; regulation of gene expression; and regulation of growth. Predicted to be located in cytoplasm. Is expressed in several structures, including egg cylinder; eye; genitourinary system; gut; and heart. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 5536.3), placenta adult (RPKM 4196.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See H19 in Genome Data Viewer
    Location:
    7 F5; 7 87.97 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142129267..142131883, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142575530..142578146, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:149724284-149724471 Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene H19/Igf2 enhancer region Neighboring gene non-coding transcript 1 Neighboring gene microRNA 675 Neighboring gene H19/Igf2 imprinting control region Neighboring gene predicted gene, 33148 Neighboring gene H19 upstream conserved region 2 Neighboring gene H19 upstream conserved region 1 Neighboring gene STARR-seq mESC enhancer starr_20515 Neighboring gene insulin-like growth factor 2 Neighboring gene microRNA 483

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The structure and expression of a novel gene activated in early mouse embryogenesis. Pachnis V, et al. EMBO J, 1988 Mar. PMID 3396539, Free PMC Article
    2. H19 controls reactivation of the imprinted gene network during muscle regeneration. Martinet C, et al. Development, 2016 Mar 15. PMID 26980793
    3. Inhibition of LncRNAH19 has the effect of anti-tumour and enhancing sensitivity to Gefitinib and Chemotherapy in Non-small-cell lung cancer in vivo. Zhou Y, et al. J Cell Mol Med, 2020 May. PMID 32281297, Free PMC Article
    4. The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns. Svensson K, et al. Development, 1998 Jan. PMID 9389664
    5. LncRNA-H19 induces hepatic stellate cell activation via upregulating alcohol dehydrogenase III-mediated retinoic acid signals. Wang ZM, et al. Int Immunopharmacol, 2020 Jul. PMID 32304991

    See all (474) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown H19 Accelerated iPSCs Reprogramming through Epigenetic Modifications and Mesenchymal-to-Epithelial Transition.
      Title: Knockdown H19 Accelerated iPSCs Reprogramming through Epigenetic Modifications and Mesenchymal-to-Epithelial Transition.
    2. Long non-coding RNA H19 promotes myoblast fibrogenesis via regulating the miR-20a-5p-Tgfbr2 axis.
      Title: Long non-coding RNA H19 promotes myoblast fibrogenesis via regulating the miR-20a-5p-Tgfbr2 axis.
    3. LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
      Title: LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
    4. LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levels.
      Title: LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levels.
    5. The long noncoding RNA lnc-H19 is important for endurance exercise by maintaining slow muscle fiber types.
      Title: The long noncoding RNA lnc-H19 is important for endurance exercise by maintaining slow muscle fiber types.
    6. [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
      Title: [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
    7. H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.
      Title: H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.
    8. Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic mice.
      Title: Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic mice.
    9. Decreased expression of H19/miR-675 ameliorates muscle atrophy by regulating the IGF1R/Akt/FoxO signaling pathway.
      Title: Decreased expression of H19/miR-675 ameliorates muscle atrophy by regulating the IGF1R/Akt/FoxO signaling pathway.
    10. In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer.
      Title: In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (172)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • H19 fetal liver mRNA

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within genomic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_130973.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK145379, BY770825, W75219
      Related
      ENSMUST00000136359.10

    2. NR_130974.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1.
      Source sequence(s)
      AK145379, BY770825, CV561038, W75219
      Related
      ENSMUST00000152754.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      142129267..142131883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023123.1: Suppressed sequence

      Description
      NM_023123.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

    2. NR_001592.1: Suppressed sequence

      Description
      NR_001592.1: This RefSeq was permanently suppressed because the transcript retains intronic sequences.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.