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    CYC1 cytochrome c1 [ Homo sapiens (human) ]

    Gene ID: 1537, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CYC1provided by HGNC
    Official Full Name
    cytochrome c1provided by HGNC
    Primary source
    HGNC:HGNC:2579
    See related
    Ensembl:ENSG00000179091 MIM:123980; AllianceGenome:HGNC:2579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UQCR4; MC3DN6
    Summary
    This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in heart (RPKM 77.6), duodenum (RPKM 50.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CYC1 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144095076..144097525)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145255893..145258315)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145149979..145152428)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene exosome component 4 Neighboring gene uncharacterized LOC124902038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19654 Neighboring gene microRNA 6847 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145144930-145145430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145145431-145145931 Neighboring gene Sharpr-MPRA regulatory region 12380 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145150053-145150248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28088 Neighboring gene SHANK associated RH domain interactor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28089 Neighboring gene Sharpr-MPRA regulatory region 2030 Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CYC1 Predicts Poor Prognosis in Patients with Breast Cancer. Han Y, et al. Dis Markers, 2016. PMID 27239088, Free PMC Article
    2. Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1. Nishikimi M, et al. Nucleic Acids Res, 1988 Apr 25. PMID 2836796, Free PMC Article
    3. Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis. Chishiki M, et al. Cancer Sci, 2017 Jul. PMID 28394473, Free PMC Article
    4. Assignment of the human cytochrome c1 gene to chromosome 8. Nishikimi M, et al. Biochem Int, 1988 Apr. PMID 2839188
    5. Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma. Sato A, et al. Histol Histopathol, 2019 Dec. PMID 31149728

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Physical contact between cytochrome c1 and cytochrome c increases the driving force for electron transfer.
      Title: Physical contact between cytochrome c(1) and cytochrome c increases the driving force for electron transfer.
    2. CYC1 inhibits cell proliferation, glycolytic activity and increases chemosensitivity to paclitaxel in ER-positive breast carcinoma cells
      Title: Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma.
    3. these results indicate that CYC1 plays important roles in cell proliferation and comedo necrosis through the elevated oxidative phosphorylation activity in human ductal carcinoma in situ
      Title: Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.
    4. results indicate that miR-661 plays a tumor suppressor role in OS mediated by the downregulation of CYC1, suggesting a potential mechanism underlying cell death resistance in Osteosarcoma.
      Title: MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.
    5. CYC1 promoted tumor metastasis via suppressing activation of AMPK and contributed to tumor growth via facilitating production of ATP.
      Title: CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
    6. FASL, granzyme B, and cytochrome c blood expression reflects breast cancer progression and response to therapy. (Review)
      Title: Apoptosis Markers in Breast Cancer Therapy.
    7. our results provide evidence that CYC1 plays an important role in OS tumorigenesis, and modulation of CYC1 may be an effective strategy to potentiate OS to apoptotic induction by TRAIL.
      Title: CYC1 silencing sensitizes osteosarcoma cells to TRAIL-induced apoptosis.
    8. Mutations in CYC1 cause insulin-responsive hyperglycemia.
      Title: Mutations in CYC1, encoding cytochrome c1 subunit of respiratory chain complex III, cause insulin-responsive hyperglycemia.
    9. HeLa cells expressing non-cleavable cytochrome c1 maintain mitochondrial morphology and functions.
      Title: Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release.
    10. Decreased electron Transport Complex IV activity is associated with ulcerative colitis.
      Title: Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Mitochondrial complex III deficiency nuclear type 6
    MedGen: C3809553 OMIM: 615453 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of cytochrome c-1 (CYC1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquinol-cytochrome-c reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to glucagon IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion HTP PubMed 
    located_in nucleus HDA PubMed 
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c1, heme protein, mitochondrial
    Names
    complex III subunit 4
    complex III subunit IV
    cytochrome b-c1 complex subunit 4
    cytochrome c-1
    ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
    NP_001907.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033872.2 RefSeqGene

      Range
      5002..7451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001916.5 → NP_001907.3  cytochrome c1, heme protein, mitochondrial precursor

      Status: REVIEWED

      Source sequence(s)
      AC104592
      Consensus CDS
      CCDS6415.1
      UniProtKB/Swiss-Prot
      P08574, Q5U062, Q6FHS7
      UniProtKB/TrEMBL
      Q8TBT6
      Related
      ENSP00000317159.4, ENST00000318911.5
      Conserved Domains (1) summary
      pfam02167
      Location:96 → 314
      Cytochrom_C1; Cytochrome C1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144095076..144097525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145255893..145258315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08574.3 GenPept UniProtKB/Swiss-Prot:P08574

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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