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    ztf-3 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ztf-3
    Official Full Name
    C2H2-type domain-containing protein
    Primary source
    WormBase:WBGene00016905
    Locus tag
    CELE_C53D5.4
    See related
    AllianceGenome:WB:WBGene00016905
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including pharynx and rectum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ztf-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (286040..289185, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-CH-type domain-containing protein Neighboring gene FAM69 protein-kinase domain-containing protein Neighboring gene Gamma-glutamyltranspeptidase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity. Methot SP, et al. Nat Cell Biol, 2021 Nov. PMID 34737442, Free PMC Article
    2. The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. Etchberger JF, et al. Genes Dev, 2007 Jul 1. PMID 17606643, Free PMC Article
    3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein
    NP_001293219.1
    • Confirmed by transcript evidence
    NP_001293220.1
    • Confirmed by transcript evidence
    NP_001359947.1
    • Confirmed by transcript evidence
    NP_001360315.1
    • Confirmed by transcript evidence
    NP_001368396.1
    • Confirmed by transcript evidence
    NP_001368397.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      286040..289185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373725.1 → NP_001359947.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5V6
      Conserved Domains (2) summary
      sd00017
      Location:233 → 253
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:231 → 253
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001373713.1 → NP_001360315.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLP3
      Conserved Domains (2) summary
      sd00017
      Location:233 → 253
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:231 → 253
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_001381400.1 → NP_001368396.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLN7
      Conserved Domains (2) summary
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:218 → 240
      zf-C2H2; Zinc finger, C2H2 type

    4. NM_001306291.3 → NP_001293220.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293220.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CKB8
      Conserved Domains (2) summary
      sd00017
      Location:83 → 103
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:81 → 103
      zf-C2H2; Zinc finger, C2H2 type

    5. NM_001381421.1 → NP_001368397.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLJ4
      Conserved Domains (2) summary
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:218 → 240
      zf-C2H2; Zinc finger, C2H2 type

    6. NM_001306290.3 → NP_001293219.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293219.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJ73
      Conserved Domains (2) summary
      sd00017
      Location:83 → 103
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:81 → 103
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein
    Heading Accession and Version

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