ddx-27 RNA helicase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ddx-27
Official Full Name: RNA helicase
Primary source: WormBase:WBGene00022148
Locus tag: CELE_Y71G12B.8
See related: AllianceGenome:WB:WBGene00022148
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be located in P granule. Predicted to be active in nucleolus. Orthologous to human DDX27 (DEAD-box helicase 27). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ddx-27 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (1767887..1790157)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y71G12A_199.a (e-PCR)
- UniSTS:324490

Y71G12A_201.a (e-PCR)
- UniSTS:324000

Y71G12A_199.b (e-PCR)
- UniSTS:323298

Y71G12A_199.c (e-PCR)
- UniSTS:323299

Y71G12A_203.c (e-PCR)
- UniSTS:323307

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA helicase

NP_490891.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1767887..1790157

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058490.5 → NP_490891.2 RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490891.2

Status: REVIEWED

UniProtKB/TrEMBL

Q95XM9

Conserved Domains (3) summary

COG0513
Location:128 → 609

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd00268
Location:150 → 354

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:379 → 488

Helicase_C; Helicase conserved C-terminal domain