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    itx-1 InTestinal NeureXin-like [ Caenorhabditis elegans ]

    Gene ID: 171846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    itx-1
    Official Full Name
    InTestinal NeureXin-like
    Primary source
    WormBase:WBGene00002174
    Locus tag
    CELE_W03D8.6
    See related
    AllianceGenome:WB:WBGene00002174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in adherens junction and basolateral plasma membrane. Is expressed in anterior ganglion; intestine; spermatheca; and vulval muscle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See itx-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    30
    Sequence:
    Chromosome: I; NC_003279.8 (2802803..2815830)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene Serine/threonine-protein phosphatase Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene Peptidase M23 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The neurexin superfamily of Caenorhabditis elegans. Haklai-Topper L, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 21055481
    2. Identification of the hydrophobic glycoproteins of Caenorhabditis elegans. Fan X, et al. Glycobiology, 2005 Oct. PMID 15888633
    3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    InTestinal NeureXin-like
    NP_001249244.2
    • Product from WormBase gene class itx;
      Partially confirmed by transcript evidence
    NP_001249245.2
    • Product from WormBase gene class itx;
      Confirmed by transcript evidence
    NP_001293382.1
    • Product from WormBase gene class itx;
      Confirmed by transcript evidence
    NP_001293383.1
    • Product from WormBase gene class itx;
      Confirmed by transcript evidence
    NP_001293384.1
    • Product from WormBase gene class itx;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2802803..2815830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306453.2 → NP_001293382.1  InTestinal NeureXin-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BS63
      Conserved Domains (3) summary
      cd00110
      Location:705 → 835
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:481 → 507
      EGF; EGF-like domain
      cl22861
      Location:1243 → 1339
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    2. NM_001262316.5 → NP_001249245.2  InTestinal NeureXin-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249245.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1ZUX6
      Conserved Domains (3) summary
      cd00110
      Location:705 → 835
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:481 → 507
      EGF; EGF-like domain
      cl22861
      Location:1243 → 1339
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. NM_001262315.4 → NP_001249244.2  InTestinal NeureXin-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249244.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45000
      Conserved Domains (3) summary
      cd00110
      Location:705 → 835
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:481 → 507
      EGF; EGF-like domain
      cl22861
      Location:1268 → 1364
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    4. NM_001306454.3 → NP_001293383.1  InTestinal NeureXin-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293383.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BPL3
      Conserved Domains (2) summary
      cd00110
      Location:538 → 668
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl22861
      Location:1076 → 1172
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    5. NM_001306455.3 → NP_001293384.1  InTestinal NeureXin-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BPJ4
      Conserved Domains (2) summary
      cd00110
      Location:538 → 668
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl22861
      Location:1076 → 1172
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    Nucleotide Protein
    Heading Accession and Version

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