U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    fog-1 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171895, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    fog-1
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00001481
    Locus tag
    CELE_Y54E10A.4
    See related
    AllianceGenome:WB:WBGene00001481
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in cell fate specification; germ-line sex determination; and spermatogenesis. Located in cytoplasm and nuclear periphery. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See fog-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (3211046..3217267)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DOMON domain-containing protein Neighboring gene rhomboid protease Neighboring gene CDT1 Geminin-binding domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. In Caenorhabditis elegans, the RNA-binding domains of the cytoplasmic polyadenylation element binding protein FOG-1 are needed to regulate germ cell fates. Jin SW, et al. Genetics, 2001 Dec. PMID 11779801, Free PMC Article
    2. Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegans. Noble DC, et al. Genetics, 2016 Jan. PMID 26564160, Free PMC Article
    3. Regulation of cell fate in Caenorhabditis elegans by a novel cytoplasmic polyadenylation element binding protein. Jin SW, et al. Dev Biol, 2001 Jan 15. PMID 11150246
    4. Functional divergence of orthologous temperature-sensitive mutations in C. elegans and C. briggsae. Velayudhan SS, et al. MicroPubl Biol, 2022. PMID 36575738, Free PMC Article
    5. Sex Determination in Nematode Germ Cells. Ellis RE. Sex Dev, 2022. PMID 35172320, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOG-1 and FOG-3 work in a complex to repress oogenic transcripts and thereby promote the sperm fate
      Title: Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegans.
    2. FOG-1 protein is barely detectable in proliferating germ cells, but abundant in germ cells destined for spermatogenesis
      Title: Dose-dependent control of proliferation and sperm specification by FOG-1/CPEB.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA regulatory element binding translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation factor activity, RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RRM domain-containing protein
    NP_001300469.1
    • Confirmed by transcript evidence
    NP_001300470.1
    • Confirmed by transcript evidence
    NP_001367956.1
    • Confirmed by transcript evidence
    NP_001367957.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3211046..3217267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381586.3 → NP_001367956.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XX9
      Conserved Domains (2) summary
      cd19757
      Location:353 → 384
      Bbox1; B-box-type 1 zinc finger (Bbox1)
      cl17169
      Location:105 → 185
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001381585.1 → NP_001367957.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBS6
      Conserved Domains (1) summary
      cl17169
      Location:319 → 399
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001313540.3 → NP_001300469.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATT1
      Conserved Domains (2) summary
      cd19757
      Location:298 → 329
      Bbox1; B-box-type 1 zinc finger (Bbox1)
      cl17169
      Location:50 → 130
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001313541.3 → NP_001300470.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQU4
      Conserved Domains (1) summary
      pfam16366
      Location:25 → 45
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools