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    eif-2beta Eukaryotic translation initiation factor 2 subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 172584, updated on 9-Dec-2024

    Summary

    Official Symbol
    eif-2beta
    Official Full Name
    Eukaryotic translation initiation factor 2 subunit 2
    Primary source
    WormBase:WBGene00010560
    Locus tag
    CELE_K04G2.1
    See related
    AllianceGenome:WB:WBGene00010560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Involved in determination of adult lifespan; regulation of growth; and translation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2 complex. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See eif-2beta in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (8026615..8027792, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cytochrome c domain-containing protein Neighboring gene RAP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Alpha/beta hydrolase domain-containing protein aho-3 Neighboring gene ATPase family protein 2 homolog

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    Eukaryotic translation initiation factor 2 subunit 2
    NP_492209.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8026615..8027792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059808.7NP_492209.1  Eukaryotic translation initiation factor 2 subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492209.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18855, Q21230
      Conserved Domains (1) summary
      smart00653
      Location:111220
      eIF2B_5; domain present in translation initiation factor eIF2B and eIF5