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    chaf-1 Chromatin assembly factor 1 subunit A dimerization domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chaf-1
    Official Full Name
    Chromatin assembly factor 1 subunit A dimerization domain-containing protein
    Primary source
    WormBase:WBGene00011532
    Locus tag
    CELE_T06D10.2
    See related
    AllianceGenome:WB:WBGene00011532
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in nucleosome assembly. Predicted to be part of CAF-1 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colon cancer; high grade glioma; neuroblastoma; and systemic lupus erythematosus. Orthologous to human CHAF1A (chromatin assembly factor 1 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chaf-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (9077565..9080024, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Abi_C domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Fatty acid desaturase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Replication-coupled chromatin assembly generates a neuronal bilateral asymmetry in C. elegans. Nakano S, et al. Cell, 2011 Dec 23. PMID 22177093, Free PMC Article
    2. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    3. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CAF-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chromatin assembly factor 1 subunit A dimerization domain-containing protein
    NP_492440.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9077565..9080024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060039.9 → NP_492440.1  Chromatin assembly factor 1 subunit A dimerization domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U380
      Conserved Domains (1) summary
      pfam12253
      Location:301 → 358
      CAF1A; Chromatin assembly factor 1 subunit A
    Nucleotide Protein
    Heading Accession and Version

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