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    ncs-2 Neuronal calcium sensor 2 [ Caenorhabditis elegans ]

    Gene ID: 172866, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncs-2
    Official Full Name
    Neuronal calcium sensor 2
    Primary source
    WormBase:WBGene00003564
    Locus tag
    CELE_F10G8.5
    See related
    AllianceGenome:WB:WBGene00003564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of signal transduction. Is expressed in nervous system. Orthologous to human RCVRN (recoverin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncs-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (10033280..10034816, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene mRNA export factor rae-1 Neighboring gene ERCC1-like central domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asynchronous Cholinergic Drive Correlates with Excitation-Inhibition Imbalance via a Neuronal Ca(2+) Sensor Protein. Zhou K, et al. Cell Rep, 2017 May 9. PMID 28494862, Free PMC Article
    2. The sequence and associated null phenotype of a C. elegans neurocalcin-like gene. Rajaram S, et al. Genesis, 2000 Apr. PMID 10748460
    3. Transgenic reporter analysis of ChIP-Seq-defined enhancers identifies novel target genes for the terminal selector UNC-3/Collier/Ebf. Li Y, et al. MicroPubl Biol, 2021. PMID 34549172, Free PMC Article
    4. The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity. Bailly AP, et al. Cell Rep, 2019 Oct 1. PMID 31577950, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neuronal calcium sensor 2
    NP_001366858.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10033280..10034816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381187.1 → NP_001366858.1  Neuronal calcium sensor 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36609
      Conserved Domains (1) summary
      COG5126
      Location:18 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36609.2

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