mgl-2 G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mgl-2
Official Full Name: G-protein coupled receptors family 3 profile domain-containing protein
Primary source: WormBase:WBGene00003233
Locus tag: CELE_F45H11.4
See related: AllianceGenome:WB:WBGene00003233
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; regulation of postsynaptic cytosolic calcium ion concentration; and regulation of postsynaptic membrane potential. Predicted to be located in plasma membrane. Is expressed in several structures, including glutamatergic neurons; head neurons; pharyngeal nervous system; somatic nervous system; and tail neurons. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to several human genes including GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mgl-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 18

Sequence:: Chromosome: I; NC_003279.8 (10383144..10391388, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Repetitive glutamate release and reversal behavior in C. elegans require the glutamate receptor MGL-2/mGluR5, expressed in RIM and other interneurons presynaptic to AVA. mgl-2 loss blocks oscillations and repetitive behavior.
Title: Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5.
Data from phylogenetic studies suggest that selective pressures on mGluR/mgl-2 structures have resulted in conservation of glutamate binding site; whereas allosteric modulator sites have been subjected to greater divergent evolutionary changes.
Title: Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F45H11.4 (e-PCR)
- UniSTS:311240

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptors family 3 profile domain-containing protein

NP_001300396.1

Partially confirmed by transcript evidence

NP_001300397.1

Partially confirmed by transcript evidence

NP_492720.3

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10383144..10391388 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001313468.4 → NP_001300397.1 G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWF7

Conserved Domains (3) summary

cd15285
Location:576 → 826

7tmC_mGluR_group1; metabotropic glutamate receptors in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:507 → 556

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:28 → 482

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
NM_060319.6 → NP_492720.3 G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492720.3

Status: REVIEWED

UniProtKB/TrEMBL

G5EG10

Conserved Domains (3) summary

cd15285
Location:576 → 826

7tmC_mGluR_group1; metabotropic glutamate receptors in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:507 → 556

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:28 → 482

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
NM_001313467.3 → NP_001300396.1 G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AU50

Conserved Domains (3) summary

cd15285
Location:576 → 826

7tmC_mGluR_group1; metabotropic glutamate receptors in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:507 → 556

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:28 → 482

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily