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    nmr-1 LITAF domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173929, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nmr-1
    Official Full Name
    LITAF domain-containing protein
    Primary source
    WormBase:WBGene00003774
    Locus tag
    CELE_F07F6.6
    See related
    AllianceGenome:WB:WBGene00003774
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity and signaling receptor activity. Predicted to contribute to NMDA glutamate receptor activity. Involved in locomotory behavior and regulation of forward locomotion. Located in neuron projection; plasma membrane; and synapse. Is expressed in several structures, including RMEV; ganglia; gonadal sheath cell; head mesodermal cell; and oocyte. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nmr-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    19
    Sequence:
    Chromosome: II; NC_003280.10 (5440238..5446606, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein dct-5 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion. Brockie PJ, et al. Neuron, 2001 Aug 30. PMID 11545720
    2. Appetitive Olfactory Learning and Long-Term Associative Memory in Caenorhabditis elegans. Nishijima S, et al. Front Behav Neurosci, 2017. PMID 28507513, Free PMC Article
    3. Nitrous oxide (N(2)O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans. Nagele P, et al. Proc Natl Acad Sci U S A, 2004 Jun 8. PMID 15159532, Free PMC Article
    4. Caenorhabditis elegans as a model for studies on quinolinic acid-induced NMDAR-dependent glutamatergic disorders. Limana da Silveira T, et al. Brain Res Bull, 2021 Oct. PMID 34271120, Free PMC Article
    5. SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans. Zheng Y, et al. Nature, 2004 Jan 29. PMID 14749834

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dopamine modulation of octanol avoidance requires NMR-1.
      Title: Dopamine modulation of avoidance behavior in Caenorhabditis elegans requires the NMDA receptor NMR-1.
    2. nmr-1 expressed in the RIM interneurons is critical for memory for context contitining.
      Title: Genetic dissection of memory for associative and non-associative learning in Caenorhabditis elegans.
    3. results show that while the osmotic avoidance response requires both NMDA and non-NMDA receptors, the response to mechanical stimuli only requires non-NMDA receptors
      Title: Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to NMDA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NMDA glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ionotropic glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of forward locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NMDA selective glutamate receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LITAF domain-containing protein
    NP_495033.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5440238..5446606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062632.7 → NP_495033.2  LITAF domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495033.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGQ9
      Conserved Domains (4) summary
      smart00714
      Location:949 → 1017
      LITAF; Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (LITAF), also known as PIG7, and other animal proteins
      cd13719
      Location:394 → 822
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:567 → 844
      Lig_chan; Ligand-gated ion channel
      cl10011
      Location:19 → 384
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version

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