Mmp7 matrix metallopeptidase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mmp7provided by MGI
Official Full Name: matrix metallopeptidase 7provided by MGI
Primary source: MGI:MGI:103189
See related: Ensembl:ENSMUSG00000018623 AllianceGenome:MGI:103189
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MAT; MMP-7
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein are deficient in functional cryptdins. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
Expression: Biased expression in large intestine adult (RPKM 146.0), small intestine adult (RPKM 25.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A1; 9 2.46 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (7692095..7699587)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (7692090..7699585)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Expression of MMP1 and MMP7 in Mice Liver after Exposure to Aflatoxin B1 Using Immunohistochemistry Technique.
Title: The Expression of MMP1 and MMP7 in Mice Liver after Exposure to Aflatoxin B1 Using Immunohistochemistry Technique.
Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis.
Title: Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis.
Matrix metalloproteinase-7 in platelet-activated macrophages accounts for cardiac remodeling in uremic mice.
Title: Matrix metalloproteinase-7 in platelet-activated macrophages accounts for cardiac remodeling in uremic mice.
Matrix Metalloproteinases Retain Soluble FasL-mediated Resistance to Cell Death in Fibrotic-Lung Myofibroblasts.
Title: Matrix Metalloproteinases Retain Soluble FasL-mediated Resistance to Cell Death in Fibrotic-Lung Myofibroblasts.
Tubular injury triggers podocyte dysfunction by beta-catenin-driven release of MMP-7.
Title: Tubular injury triggers podocyte dysfunction by β-catenin-driven release of MMP-7.
Study results suggest that induction of MMP-7 is protective in acute kidney injury by degrading FasL and mobilizing beta-catenin, thereby priming kidney tubules for survival and regeneration.
Title: Matrix metalloproteinase-7 protects against acute kidney injury by priming renal tubules for survival and regeneration.
FXR suppresses MMP7 transcription by binding to a negative FXR-responsive element in the 5' MMP7 promoter, an event that inhibited colon cancer cell proliferation and invasion.
Title: Farnesoid X receptor represses matrix metalloproteinase 7 expression, revealing this regulatory axis as a promising therapeutic target in colon cancer.
The authors show that the antimicrobial peptide alpha-defensin is functionally sustained during nutrient deprivation because of regulation of the defensin-processing enzyme MMP7 by microbiota- and host-derived factors. Sustained Mmp7 expression requires the microbiota and is mediated by de-repression of the transcription activator Atoh1 upon attenuation of the transcriptional repressor Hes1 in intestinal epithelial cells.
Title: Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1.
Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression is associated with Aneurysm Severity.
Title: Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.
upregulating MMP7 levels may be key to remove remyelination-impairing fibronectin aggregates in multiple sclerosis lesions
Title: MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mmp7 (e-PCR), detects polymorphism
- UniSTS:143883

Mmp7 (e-PCR), detects polymorphism
- UniSTS:143884

Mmp7 (e-PCR), detects polymorphism
- UniSTS:526864

Mmp7 (e-PCR), detects polymorphism
- UniSTS:259373

NoName (e-PCR)
- UniSTS:491343

D9Mit57 (e-PCR), detects polymorphism
- UniSTS:131943

Mmp7 (e-PCR), detects polymorphism
- UniSTS:265624

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	TAS Traceable Author Statement more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antibacterial peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein intracellular domain proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane protein intracellular domain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: matrilysin

Names: matrilysin, uterine; matrin; matrix metalloproteinase 7; pump-1 protease; uterine metalloproteinase

NP_001306915.1

EC 3.4.24.23

NP_034940.3

EC 3.4.24.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001319986.2 → NP_001306915.1 matrilysin isoform 2

Status: REVIEWED

Source sequence(s)

AL603630

UniProtKB/TrEMBL

Q3UN27

Related

ENSMUST00000249869.1

Conserved Domains (3) summary

cd04278
Location:70 → 226

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:70 → 226

Peptidase_M10; Matrixin

pfam01471
Location:4 → 49

PG_binding_1; Putative peptidoglycan binding domain
NM_010810.6 → NP_034940.3 matrilysin isoform 1 preproprotein

Status: REVIEWED

Source sequence(s)

AL603630

Consensus CDS

CCDS40531.1

UniProtKB/Swiss-Prot

Q10738

Related

ENSMUSP00000018767.9, ENSMUST00000018767.9