snt-1 C2 domain-containing protein;Synaptotagmin-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: snt-1
Official Full Name: C2 domain-containing protein;Synaptotagmin-1
Primary source: WormBase:WBGene00004921
Locus tag: CELE_F31E8.2
See related: AllianceGenome:WB:WBGene00004921
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium ion binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Involved in several processes, including defecation; regulation of nematode pharyngeal pumping; and synaptic vesicle endocytosis. Located in synaptic vesicle. Is expressed in several structures, including excretory gland cell; gonad; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and congenital myasthenic syndrome 7. Orthologous to several human genes including SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See snt-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (6810963..6816433)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release.
Title: A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release.
Involvement of the synaptotagmin/stonin2 system in vesicular transport regulated by semaphorins in Caenorhabditis elegans epidermal cells.
Title: Involvement of the synaptotagmin/stonin2 system in vesicular transport regulated by semaphorins in Caenorhabditis elegans epidermal cells.
we show that snt-1 functions as the Ca(2+) sensor for both tonic and evoked neurotransmitter release at the Caenorhabditis elegans neuromuscular junction
Title: SNT-1 Functions as the Ca(2+) Sensor for Tonic and Evoked Neurotransmitter Release in Caenorhabditis Elegans.
Data show that without synaptotagmin 1, the tight coupling between vesicle exocytosis and Rab3 GTP-binding protein membrane disassociation is disrupted.
Title: Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F31E8.2 (e-PCR)
- UniSTS:319292

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion sensor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in synaptic vesicle exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in dense core granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C2 domain-containing protein;Synaptotagmin-1

NP_001022129.1

Confirmed by transcript evidence

NP_495394.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6810963..6816433

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026958.6 → NP_001022129.1 Synaptotagmin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022129.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34693

Conserved Domains (2) summary

cd08385
Location:160 → 282

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:293 → 427

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
NM_062993.9 → NP_495394.3 C2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495394.3

Status: REVIEWED

UniProtKB/TrEMBL

Q95QH7

Conserved Domains (2) summary

cd08385
Location:160 → 282

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:293 → 429

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1