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    R53.5 Peroxiredoxin-like 2A [ Caenorhabditis elegans ]

    Gene ID: 174555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    R53.5
    Official Full Name
    Peroxiredoxin-like 2A
    Primary source
    WormBase:WBGene00011274
    Locus tag
    CELE_R53.5
    See related
    AllianceGenome:WB:WBGene00011274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable antioxidant activity. Predicted to be involved in cellular oxidant detoxification. Predicted to be active in cytoplasm. Is expressed in several structures, including coelomocyte; head mesodermal cell; intestine; nervous system; and rectal gland cell. Orthologous to human PRXL2A (peroxiredoxin like 2A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See R53.5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (9969620..9970488, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative ATP synthase subunit f, mitochondrial Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative DNA replication complex GINS protein PSF1 Neighboring gene CBS domain-containing protein Neighboring gene AMIN domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antioxidant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Peroxiredoxin-like 2A
    NP_496154.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9969620..9970488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063753.6 → NP_496154.1  Peroxiredoxin-like 2A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22020
      Conserved Domains (1) summary
      cd02970
      Location:59 → 196
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    Nucleotide Protein
    Heading Accession and Version

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