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    Y39G8B.1 NADP-dependent oxidoreductase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175047, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y39G8B.1
    Official Full Name
    NADP-dependent oxidoreductase domain-containing protein
    Primary source
    WormBase:WBGene00012722
    Locus tag
    CELE_Y39G8B.1
    See related
    AllianceGenome:WB:WBGene00012722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; congenital bile acid synthesis defect 2; diabetic neuropathy; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B); AKR1B10 (aldo-keto reductase family 1 member B10); and AKR1B15 (aldo-keto reductase family 1 member B15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y39G8B.1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (13970580..13973812, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene NADP-dependent oxidoreductase domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class E (Epsilon)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADP-dependent oxidoreductase domain-containing protein
    NP_001370070.1
    • Confirmed by transcript evidence
    NP_496924.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13970580..13973812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064523.3 → NP_496924.1  NADP-dependent oxidoreductase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2J6
      Conserved Domains (1) summary
      cl00470
      Location:7 → 301
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    2. NM_001383987.1 → NP_001370070.1  NADP-dependent oxidoreductase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAI5
      Conserved Domains (1) summary
      cl00470
      Location:7 → 305
      AKR_SF; Aldo-keto reductase (AKR) superfamily
    Nucleotide Protein
    Heading Accession and Version

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