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    syx-16 t-SNARE coiled-coil homology domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    syx-16
    Official Full Name
    t-SNARE coiled-coil homology domain-containing protein
    Primary source
    WormBase:WBGene00022534
    Locus tag
    CELE_ZC155.7
    See related
    AllianceGenome:WB:WBGene00022534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in Golgi apparatus and membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type IB. Orthologous to human STX16 (syntaxin 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See syx-16 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (5207567..5209109, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Molybdopterin synthase sulfur carrier subunit Neighboring gene NADPH--cytochrome P450 reductase Neighboring gene ATPase morc-1 Neighboring gene ncRNA Neighboring gene GP-PDE domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans SNAP-29 is required for organellar integrity of the endomembrane system and general exocytosis in intestinal epithelial cells. Sato M, et al. Mol Biol Cell, 2011 Jul 15. PMID 21613542, Free PMC Article
    2. Depletion of syntaxins in the early Caenorhabditis elegans embryo reveals a role for membrane fusion events in cytokinesis. Jantsch-Plunger V, et al. Curr Biol, 1999 Jul 15. PMID 10421575
    3. The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. Gengyo-Ando K, et al. EMBO Rep, 2007 Feb. PMID 17235359, Free PMC Article
    4. The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology. Luo L, et al. Mol Biol Cell, 2011 Jul 15. PMID 21613545, Free PMC Article
    5. Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans. Liu Z, et al. Proc Natl Acad Sci U S A, 2020 Feb 11. PMID 31988138, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    t-SNARE coiled-coil homology domain-containing protein
    NP_001379771.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5207567..5209109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392089.1 → NP_001379771.1  t-SNARE coiled-coil homology domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TY08
      Conserved Domains (2) summary
      COG5325
      Location:69 → 316
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15845
      Location:238 → 296
      SNARE_syntaxin16; SNARE motif of syntaxin 16
    Nucleotide Protein
    Heading Accession and Version

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