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    gphr-1 Golgi pH regulator [ Caenorhabditis elegans ]

    Gene ID: 176650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gphr-1
    Official Full Name
    Golgi pH regulator
    Primary source
    WormBase:WBGene00013551
    Locus tag
    CELE_Y75B8A.16
    See related
    AllianceGenome:WB:WBGene00013551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable voltage-gated monoatomic anion channel activity. Predicted to be involved in intracellular pH reduction. Predicted to be located in membrane. Predicted to be active in Golgi cisterna membrane. Orthologous to human GPR89A (G protein-coupled receptor 89A) and GPR89B (G protein-coupled receptor 89B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gphr-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (12219047..12223936)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene titin Neighboring gene ncRNA Neighboring gene GPN-loop GTPase 3 Neighboring gene Geminin homolog Neighboring gene Clathrin light chain Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular pH reduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi pH regulator
    NP_001407531.1
    • Confirmed by transcript evidence
    NP_001407532.1
    • Confirmed by transcript evidence
    NP_499588.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12219047..12223936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067187.6 → NP_499588.1  Golgi pH regulator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1S3
      Conserved Domains (2) summary
      pfam12430
      Location:285 → 452
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:144 → 210
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    2. NM_001420557.1 → NP_001407531.1  Golgi pH regulator [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4SS68

    3. NM_001420558.1 → NP_001407532.1  Golgi pH regulator [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4SRQ8
    Nucleotide Protein
    Heading Accession and Version

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