ced-2 Cell death abnormality protein 2;SH3 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ced-2
Official Full Name: Cell death abnormality protein 2;SH3 domain-containing protein
Primary source: WormBase:WBGene00000416
Locus tag: CELE_Y41D4B.13
See related: AllianceGenome:WB:WBGene00000416
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Involved in several processes, including engulfment of apoptotic cell; positive regulation of distal tip cell migration; and positive regulation of engulfment of apoptotic cell. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein) and CRK (CRK proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ced-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (1597318..1601621)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CED-2 may regulate cell corpse engulfment by interacting with CED-5 through the N-terminal region rather than the PXXP motif.
Title: Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y41D4A_3457.c (e-PCR)
- UniSTS:324321

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in enzyme-linked receptor protein signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Cell death abnormality protein 2;SH3 domain-containing protein

NP_001368287.1

Confirmed by transcript evidence

NP_001368288.1

Confirmed by transcript evidence

NP_500105.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

1597318..1601621

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067704.7 → NP_500105.1 Cell death abnormality protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500105.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NHC3

Conserved Domains (3) summary

cd11767
Location:120 → 173

SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins

cl15255
Location:6 → 116

SH2; Src homology 2 (SH2) domain

cl17036
Location:218 → 274

SH3; Src Homology 3 domain superfamily
NM_001380050.1 → NP_001368287.1 SH3 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PMJ0

Conserved Domains (1) summary

cl17036
Location:44 → 100

SH3; Src Homology 3 domain superfamily
NM_001380051.1 → NP_001368288.1 Cell death abnormality protein 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PRV3

Conserved Domains (1) summary

cl17036
Location:6 → 22

SH3; Src Homology 3 domain superfamily