paqr-1 Adiponectin receptor protein 1;Progestin and adipoQ receptor-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: paqr-1
Official Full Name: Adiponectin receptor protein 1;Progestin and adipoQ receptor-like protein 1
Primary source: WormBase:WBGene00016610
Locus tag: CELE_C43G2.1
See related: AllianceGenome:WB:WBGene00016610
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable signaling receptor activity. Involved in positive regulation of fatty acid oxidation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including excretory canal; intestine; mechanosensory neurons; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in breast cancer; macular degeneration; metabolic dysfunction-associated steatotic liver disease; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to several human genes including ADIPOR1 (adiponectin receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See paqr-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (6552425..6555438, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
Title: Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C43G2.1 (e-PCR)
- UniSTS:313857

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fatty acid oxidation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Adiponectin receptor protein 1;Progestin and adipoQ receptor-like protein 1

NP_001367391.1

Confirmed by transcript evidence

NP_001368383.1

Confirmed by transcript evidence

NP_001368705.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6552425..6555438 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380277.2 → NP_001367391.1 Progestin and adipoQ receptor-like protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94177

Conserved Domains (1) summary

pfam03006
Location:195 → 416

HlyIII; Haemolysin-III related
NM_001380278.1 → NP_001368705.1 Progestin and adipoQ receptor-like protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E8S8

Conserved Domains (1) summary

pfam03006
Location:195 → 422

HlyIII; Haemolysin-III related
NM_001380279.1 → NP_001368383.1 Adiponectin receptor protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLD5

Conserved Domains (1) summary

pfam03006
Location:96 → 317

HlyIII; Haemolysin-III related