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    pmk-2 Mitogen-activated protein kinase pmk-2;mitogen-activated protein kinase [ Caenorhabditis elegans ]

    Gene ID: 177611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pmk-2
    Official Full Name
    Mitogen-activated protein kinase pmk-2;mitogen-activated protein kinase
    Primary source
    WormBase:WBGene00004056
    Locus tag
    CELE_F42G8.3
    See related
    AllianceGenome:WB:WBGene00004056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables MAP kinase activity. Involved in intracellular signal transduction and response to osmotic stress. Located in cytoplasm. Is expressed in ganglia; gonad; intestine; and somatic nervous system. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to several human genes including MAPK11 (mitogen-activated protein kinase 11) and MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pmk-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (8143500..8148648)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Interactor with SLO-1 Neighboring gene Mitogen-activated protein kinase pmk-3;Protein kinase domain-containing protein Neighboring gene Mitogen-activated protein kinase pmk-1 Neighboring gene Amidase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue expression pattern of PMK-2 p38 MAPK is established by the miR-58 family in C. elegans. Pagano DJ, et al. PLoS Genet, 2015 Feb. PMID 25671546, Free PMC Article
    2. Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Berman K, et al. Mol Cell Biol Res Commun, 2001 Nov. PMID 11703092, Free PMC Article
    3. A C. elegans MAP kinase pathway is required for wild-type display of an L1-specific surface antigen (srf-6 is nsy-1 III). Foley S, et al. MicroPubl Biol, 2019 Jul 4. PMID 32550420, Free PMC Article
    4. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Kim DH, et al. Science, 2002 Jul 26. PMID 12142542
    5. The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Inoue H, et al. Genes Dev, 2005 Oct 1. PMID 16166371, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mitogen-activated protein kinase pmk-2;mitogen-activated protein kinase
    NP_001368440.1
    • Confirmed by transcript evidence
    NP_001368441.1
    • Confirmed by transcript evidence
    NP_741457.2
    • Confirmed by transcript evidence
    NP_741458.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8143500..8148648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171392.7 → NP_741457.2  Mitogen-activated protein kinase pmk-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741457.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MXI3, Q8MXI4
      Conserved Domains (1) summary
      cd07851
      Location:33 → 381
      STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase

    2. NM_171913.6 → NP_741458.2  Mitogen-activated protein kinase pmk-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741458.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MXI3, Q8MXI4
      Conserved Domains (2) summary
      cd07851
      Location:33 → 376
      STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase
      smart00220
      Location:49 → 333
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    3. NM_001380352.1 → NP_001368440.1  mitogen-activated protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6SBC9
      Conserved Domains (1) summary
      cl21453
      Location:1 → 178
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001380353.1 → NP_001368441.1  mitogen-activated protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RQY6
      Conserved Domains (1) summary
      cl21453
      Location:1 → 173
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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