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    hacd-1 3-hydroxyacyl-CoA dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 178638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hacd-1
    Official Full Name
    3-hydroxyacyl-CoA dehydrogenase
    Primary source
    WormBase:WBGene00019978
    Locus tag
    CELE_R09B5.6
    See related
    AllianceGenome:WB:WBGene00019978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in membrane and mitochondrial matrix. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hacd-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (1460369..1461613)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Glyco_18 domain-containing protein Neighboring gene Solute carrier family 40 member Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. Svensk E, et al. PLoS Genet, 2013. PMID 24068966, Free PMC Article
    2. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert S, et al. Genes Dev, 2006 May 1. PMID 16651656, Free PMC Article
    3. Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity. Arneaud SLB, et al. Aging Cell, 2022 Sep. PMID 35977034, Free PMC Article
    4. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans. Abete-Luzi P, et al. Genetics, 2020 Mar. PMID 31974205, Free PMC Article
    5. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyacyl-CoA dehydrogenase
    NP_503421.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1460369..1461613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071020.10 → NP_503421.1  3-hydroxyacyl-CoA dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44608
      Conserved Domains (3) summary
      COG1250
      Location:13 → 299
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
      pfam00725
      Location:202 → 299
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:13 → 200
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
    Nucleotide Protein
    Heading Accession and Version

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