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    tnt-4 Troponin T, skeletal muscle [ Caenorhabditis elegans ]

    Gene ID: 178679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tnt-4
    Official Full Name
    Troponin T, skeletal muscle
    Primary source
    WormBase:WBGene00006589
    Locus tag
    CELE_T08B1.2
    See related
    AllianceGenome:WB:WBGene00006589
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tropomyosin binding activity. Involved in several processes, including nematode larval development; nematode pharyngeal gland morphogenesis; and nematode pharynx development. Predicted to be part of troponin complex. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and muscle tissue disease (multiple). Orthologous to human TNNT1 (troponin T1, slow skeletal type); TNNT2 (troponin T2, cardiac type); and TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tnt-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (1989471..1992918, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene Aldehyde dehydrogenase Neighboring gene C-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans. Ruksana R, et al. Genes Cells, 2005 Mar. PMID 15743415
    2. Integration of male mating and feeding behaviors in Caenorhabditis elegans. Gruninger TR, et al. J Neurosci, 2006 Jan 4. PMID 16399684, Free PMC Article
    3. Tissue-specific interactions of TNI isoforms with other TN subunits and tropomyosins in C. elegans: the role of the C- and N-terminal extensions. Amin MZ, et al. Biochim Biophys Acta, 2007 Apr. PMID 17369112
    4. Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling. Mallick A, et al. iScience, 2020 Dec 18. PMID 33319173, Free PMC Article
    5. Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx. Raharjo WH, et al. Genetics, 2011 Nov. PMID 21868609, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gene duplication led to evolution of troponin I
      Title: Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode pharyngeal gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Troponin T, skeletal muscle
    NP_001263832.1
    • Confirmed by transcript evidence
    NP_503544.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1989471..1992918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071143.6 → NP_503544.2  Troponin T, skeletal muscle [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503544.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44556

    2. NM_001276903.3 → NP_001263832.1  Troponin T, skeletal muscle [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263832.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ERV5
    Nucleotide Protein
    Heading Accession and Version

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