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    F44E7.4 Insulin-degrading enzyme [ Caenorhabditis elegans ]

    Gene ID: 178966, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F44E7.4
    Official Full Name
    Insulin-degrading enzyme
    Primary source
    WormBase:WBGene00018426
    Locus tag
    CELE_F44E7.4
    See related
    AllianceGenome:WB:WBGene00018426
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide catabolic process and proteolysis involved in protein catabolic process. Predicted to be active in cytosol and mitochondrion. Is expressed in gonad. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F44E7.4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (5772831..5776953, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Phosphoglycolate phosphatase Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene pseudo Neighboring gene F-box domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Insulin-degrading enzyme
    NP_001023928.1
    • Confirmed by transcript evidence
    NP_504514.2
    • Confirmed by transcript evidence
    NP_741542.1
    • Confirmed by transcript evidence
    NP_741543.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5772831..5776953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171929.7 → NP_741543.1  Insulin-degrading enzyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741543.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16249
      Conserved Domains (4) summary
      COG1025
      Location:75 → 1039
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:95 → 233
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:259 → 436
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:444 → 744
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    2. NM_072113.8 → NP_504514.2  Insulin-degrading enzyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504514.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IA89
      Conserved Domains (4) summary
      COG1025
      Location:16 → 980
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:36 → 174
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:200 → 377
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:385 → 685
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    3. NM_171461.5 → NP_741542.1  Insulin-degrading enzyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741542.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXK1
      Conserved Domains (4) summary
      COG1025
      Location:75 → 1023
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:95 → 233
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:259 → 436
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:444 → 728
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    4. NM_001028757.6 → NP_001023928.1  Insulin-degrading enzyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6A598
      Conserved Domains (4) summary
      COG1025
      Location:75 → 982
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:95 → 233
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:259 → 436
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:444 → 744
      Peptidase_M16_M; Middle or third domain of peptidase_M16
    Nucleotide Protein
    Heading Accession and Version

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