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    ifbp-1 IRF-2BP1_2 domain-containing protein;Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein;RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179817, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ifbp-1
    Official Full Name
    IRF-2BP1_2 domain-containing protein;Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein;RING-type domain-containing protein
    Primary source
    WormBase:WBGene00010867
    Locus tag
    CELE_M04G12.1
    See related
    AllianceGenome:WB:WBGene00010867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in common variable immunodeficiency 14 and neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures. Orthologous to several human genes including IRF2BP2 (interferon regulatory factor 2 binding protein 2) and IRF2BPL (interferon regulatory factor 2 binding protein like). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ifbp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (13370083..13380262, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Serpentine receptor class gamma-46 Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene cathepsin X Neighboring gene Soluble guanylate cyclase gcy-34 Neighboring gene Zinc finger protein somi-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut. Kiefer JC, et al. Dev Biol, 2007 Mar 15. PMID 17250823, Free PMC Article
    2. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IRF-2BP1_2 domain-containing protein;Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein;RING-type domain-containing protein
    NP_001256503.1
    • Confirmed by transcript evidence
    NP_001294707.1
    • Confirmed by transcript evidence
    NP_001360553.1
    • Confirmed by transcript evidence
    NP_001360554.1
    • Confirmed by transcript evidence
    NP_001360556.1
    • Confirmed by transcript evidence
    NP_001360557.1
    • Confirmed by transcript evidence
    NP_001367188.1
    • Confirmed by transcript evidence
    NP_001368733.1
    • Confirmed by transcript evidence
    NP_506316.1
    • Confirmed by transcript evidence
    NP_506317.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13370083..13380262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073915.6 → NP_506316.1  Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVK9
      Conserved Domains (2) summary
      cd16511
      Location:269 → 324
      vRING-HC_IRF2BP1_like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins
      pfam11261
      Location:49 → 98
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

    2. NM_073916.5 → NP_506317.2  Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506317.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P92004
      Conserved Domains (2) summary
      cd16511
      Location:296 → 351
      vRING-HC_IRF2BP1_like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins
      pfam11261
      Location:76 → 125
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

    3. NM_001373140.3 → NP_001360554.1  Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WWY4
      Conserved Domains (2) summary
      cd16511
      Location:296 → 351
      vRING-HC_IRF2BP1_like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins
      pfam11261
      Location:76 → 125
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

    4. NM_001373139.2 → NP_001360553.1  Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WVP3
      Conserved Domains (2) summary
      cd16511
      Location:269 → 324
      vRING-HC_IRF2BP1_like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins
      pfam11261
      Location:49 → 98
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

    5. NM_001380801.1 → NP_001368733.1  Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WXY0
      Conserved Domains (2) summary
      pfam11261
      Location:38 → 89
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger
      cd16511
      Location:259 → 314
      vRING-HC_IRF2BP1-like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins

    6. NM_001380802.1 → NP_001367188.1  Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2D6P5
      Conserved Domains (2) summary
      cd16511
      Location:259 → 314
      vRING-HC_IRF2BP1_like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins
      pfam11261
      Location:38 → 89
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

    7. NM_001269574.3 → NP_001256503.1  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256503.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6V0
      Conserved Domains (1) summary
      cd16511
      Location:111 → 166
      vRING-HC_IRF2BP1_like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins

    8. NM_001373142.2 → NP_001360556.1  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WTX8
      Conserved Domains (1) summary
      cd16511
      Location:111 → 166
      vRING-HC_IRF2BP1_like; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins

    9. NM_001373143.2 → NP_001360557.1  IRF-2BP1_2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WXA8
      Conserved Domains (1) summary
      cl17238
      Location:1 → 13
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    10. NM_001307778.3 → NP_001294707.1  IRF-2BP1_2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NV21
      Conserved Domains (1) summary
      cl17238
      Location:1 → 13
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
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