unc-76 MitMem_reg domain-containing protein;UNC-76 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: unc-76
Official Full Name: MitMem_reg domain-containing protein;UNC-76
Primary source: WormBase:WBGene00006808
Locus tag: CELE_C01G10.11
See related: AllianceGenome:WB:WBGene00006808
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables syntaxin binding activity. Involved in several processes, including anterograde axonal protein transport; axonal fasciculation; and regulation of axon extension. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in neurons and somatic nervous system. Orthologous to several human genes including FEZ1 (fasciculation and elongation protein zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Data show that mutants in UNC-16 and UNC-76 increased mitochondrial density and also have elevated levels of both the Kinesin Heavy and Light Chains in neurons.
Title: UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables kinesin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IC Inferred by Curator more info	PubMed
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde axonal protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed