dlg-1 Disks large homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dlg-1
Official Full Name: Disks large homolog 1
Primary source: WormBase:WBGene00001006
Locus tag: CELE_C25F6.2
See related: AllianceGenome:WB:WBGene00001006
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanylate kinase activity and protein kinase binding activity. Involved in embryo development and zonula adherens assembly. Located in adherens junction and apical junction complex. Is expressed in several structures, including epithelial cell; germ line; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; invasive ductal carcinoma; and non-syndromic X-linked intellectual disability 90. Orthologous to several human genes including DLG1 (discs large MAGUK scaffold protein 1); DLG3 (discs large MAGUK scaffold protein 3); and DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dlg-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (5479700..5484941)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Translation-dependent mRNA localization to Caenorhabditis elegans adherens junctions.
Title: Translation-dependent mRNA localization to Caenorhabditis elegans adherens junctions.
MAPH-1.1 is a microtubule-associated protein of the MAP1 family and a candidate neuron-specific interaction partner of DLG-1.
Title: A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.
The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1.
Title: The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1.
requirement for LET-413 and DLG-1 in the polarization of the spermathecal cells
Title: Increased IP3/Ca2+ signaling compensates depletion of LET-413/DLG-1 in C. elegans epithelial junction assembly.
These results represent the first in vivo analysis of requirements for the L27 domain of a Discs-large/SAP97 protein, identify a crucial LET-413/Scribble regulatory motif.
Title: Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C25F6.2 (e-PCR)
- UniSTS:309143

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables guanylate kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in GDP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in zonula adherens assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical junction complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Disks large homolog 1

NP_001024431.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5479700..5484941

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029260.5 → NP_001024431.1 Disks large homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024431.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECY0, Q7Z124

Conserved Domains (5) summary

cd11861
Location:623 → 684

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:776 → 944

GuKc; Guanylate kinase homologues

smart00228
Location:507 → 591

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:361 → 445

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09058
Location:7 → 63

L27_1; L27_1