mec-2 Band 7 domain-containing protein;Mechanosensory protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-2
Official Full Name: Band 7 domain-containing protein;Mechanosensory protein 2
Primary source: WormBase:WBGene00003166
Locus tag: CELE_F14D12.4
See related: AllianceGenome:WB:WBGene00003166
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cholesterol binding activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. Located in neuron projection membrane. Is expressed in nervous system. Used to study nephrotic syndrome. Orthologous to human STOM (stomatin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mec-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 19

Sequence:: Chromosome: X; NC_003284.9 (5567754..5590830)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sensory neuron transcriptomes reveal complex neuron-specific function and regulation of mec-2/Stomatin splicing.
Title: Sensory neuron transcriptomes reveal complex neuron-specific function and regulation of mec-2/Stomatin splicing.
Ubiquitin ligase Ubr4 is responsible for the degradation of mislocalized MEC-2 multimers. Ubiquitylation of one MEC-2 site, K301, do not only target MEC-2 for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex.
Title: The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
the carboxyl terminus of podocin/MEC-2 has to be placed at the inner leaflet of the plasma membrane to mediate cholesterol binding and contribute to ion channel activity.
Title: A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin.
[review] Similarly to stomatins from other species, C. elegans counterparts may also be membrane proteins with intracellular amino- and carboxyl-terminals.
Title: Stomatin-domain proteins.
MEC-2 with MEC-6 increase open probability of ENaC (constitutively active MEC-4/MEC-10 in Xenopus oocytes), decrease the efficiency of Ca2+ block. Its palmitoylation and cholesterol-binding activity are required for channel activation
Title: MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: auxiliary subunits that enable channel activity.
MEC-2, Podocin, and probably many other PHB-domain proteins by binding to themselves, cholesterol, and target proteins regulate the formation and function of large protein-cholesterol supercomplexes in the plasma membrane
Title: Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F14D12.4 (e-PCR)
- UniSTS:313070

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cholesterol binding	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Band 7 domain-containing protein;Mechanosensory protein 2

NP_001024566.1

Confirmed by transcript evidence

NP_001024567.1

Confirmed by transcript evidence

NP_001355457.1

Confirmed by transcript evidence

NP_001355458.1

Confirmed by transcript evidence

NP_001355459.1

Confirmed by transcript evidence

NP_001355460.1

Confirmed by transcript evidence

NP_001355478.1

Confirmed by transcript evidence

NP_001355479.1

Confirmed by transcript evidence

NP_001355480.1

Confirmed by transcript evidence

NP_001368710.1

Confirmed by transcript evidence

NP_001368712.1

Confirmed by transcript evidence

NP_001368713.1

Confirmed by transcript evidence

NP_001368714.1

Confirmed by transcript evidence

NP_001368715.1

Confirmed by transcript evidence

NP_001368716.1

Confirmed by transcript evidence

NP_001368717.1

Confirmed by transcript evidence

NP_741797.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5567754..5590830

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001368504.4 → NP_001355460.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DQJ7

Conserved Domains (1) summary

cd03403
Location:78 → 279

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001368508.5 → NP_001355458.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E532

Conserved Domains (1) summary

cd03403
Location:101 → 302

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001380971.2 → NP_001368710.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DVR7

Conserved Domains (2) summary

PTZ00121
Location:512 → 854

PTZ00121; MAEBL; Provisional

cd03403
Location:101 → 302

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001368507.2 → NP_001355459.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E8U1

Conserved Domains (1) summary

cd03403
Location:101 → 302

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001368505.3 → NP_001355457.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E3V6

Conserved Domains (1) summary

cd03403
Location:101 → 302

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_171691.6 → NP_741797.1 Mechanosensory protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741797.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27433

Conserved Domains (2) summary

smart00244
Location:139 → 291

PHB; prohibitin homologues

cd03403
Location:160 → 361

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001380972.1 → NP_001368712.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E057

Conserved Domains (2) summary

PTZ00121
Location:571 → 913

PTZ00121; MAEBL; Provisional

cd03403
Location:160 → 361

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001380973.1 → NP_001368715.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E9Z8

Conserved Domains (1) summary

cd03403
Location:160 → 361

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001029395.4 → NP_001024566.1 Band 7 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024566.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQ74

Conserved Domains (1) summary

cd03403
Location:160 → 361

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001368514.4 → NP_001355480.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DQN5

Conserved Domains (1) summary

cd03403
Location:93 → 294

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001368511.3 → NP_001355478.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E553

Conserved Domains (1) summary

cd03403
Location:93 → 294

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001380974.1 → NP_001368713.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DVV1

Conserved Domains (2) summary

PTZ00121
Location:504 → 846

PTZ00121; MAEBL; Provisional

cd03403
Location:93 → 294

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001380975.1 → NP_001368716.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E520

Conserved Domains (1) summary

cd03403
Location:93 → 294

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001029396.4 → NP_001024567.1 Band 7 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024567.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZ92

Conserved Domains (1) summary

cd03403
Location:85 → 286

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001368515.4 → NP_001355479.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E8U8

Conserved Domains (1) summary

cd03403
Location:85 → 286

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001380976.1 → NP_001368714.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1E3Y0

Conserved Domains (2) summary

PTZ00121
Location:496 → 838

PTZ00121; MAEBL; Provisional

cd03403
Location:85 → 286

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001380977.1 → NP_001368717.1 Band 7 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DR76

Conserved Domains (1) summary

cd03403
Location:85 → 286

SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily