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    mup-2 Troponin T [ Caenorhabditis elegans ]

    Gene ID: 180914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mup-2
    Official Full Name
    Troponin T
    Primary source
    WormBase:WBGene00003495
    Locus tag
    CELE_T22E5.5
    See related
    AllianceGenome:WB:WBGene00003495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tropomyosin binding activity. Involved in several processes, including axonal fasciculation; larval somatic muscle development; and sarcomere organization. Predicted to be part of troponin complex. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and muscle tissue disease (multiple). Orthologous to human TNNT1 (troponin T1, slow skeletal type); TNNT2 (troponin T2, cardiac type); and TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mup-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (6408471..6410227, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Amino acid transporter;Putative sodium-dependent excitatory amino acid transporter glt-4 Neighboring gene ncRNA Neighboring gene Accessory protein 7b;Zf-C5HC2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental genetic analysis of troponin T mutations in striated and nonstriated muscle cells of Caenorhabditis elegans. Myers CD, et al. J Cell Biol, 1996 Mar. PMID 8601585, Free PMC Article
    2. Mutations affecting nerve attachment of Caenorhabditis elegans. Shioi G, et al. Genetics, 2001 Apr. PMID 11290717, Free PMC Article
    3. A local, high-density, single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1. Jakubowski J, et al. Genetics, 1999 Oct. PMID 10511554, Free PMC Article
    4. The POU gene ceh-18 promotes gonadal sheath cell differentiation and function required for meiotic maturation and ovulation in Caenorhabditis elegans. Rose KL, et al. Dev Biol, 1997 Dec 1. PMID 9405097
    5. Ca2+-dependent muscle dysfunction caused by mutation of the Caenorhabditis elegans troponin T-1 gene. McArdle K, et al. J Cell Biol, 1998 Nov 30. PMID 9832549, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of troponin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Troponin T
    NP_509076.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6408471..6410227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076675.10 → NP_509076.1  Troponin T [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27371
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27371.1

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