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    cdf-1 Cation diffusion facilitator family protein 1;Zinc transporter 1 [ Caenorhabditis elegans ]

    Gene ID: 180923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdf-1
    Official Full Name
    Cation diffusion facilitator family protein 1;Zinc transporter 1
    Primary source
    WormBase:WBGene00000393
    Locus tag
    CELE_C15B12.7
    See related
    AllianceGenome:WB:WBGene00000393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase binding activity. Involved in cellular response to zinc ion; positive regulation of Ras protein signal transduction; and positive regulation of vulval development. Located in basolateral plasma membrane. Is expressed in several structures, including P5.p hermaphrodite; P6.p hermaphrodite; P7.p hermaphrodite; rectal valve cell; and vulval cell. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to several human genes including SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdf-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (6499916..6505133, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ACT1-like protein Neighboring gene Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells of Caenorhabditis elegans. Sharma AK, et al. Front Physiol, 2023. PMID 37822680, Free PMC Article
    2. Cation diffusion facilitator proteins modulate Raf-1 activity. Jirakulaporn T, et al. J Biol Chem, 2004 Jun 25. PMID 15096503
    3. ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. Roh HC, et al. PLoS Genet, 2013 May. PMID 23717214, Free PMC Article
    4. Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genomewide map of single nucleotide polymorphisms scored by pyrosequencing. Bruinsma JJ, et al. Genetics, 2008 Jun. PMID 18505880, Free PMC Article
    5. SLC30A10: A novel manganese transporter. Chen P, et al. Worm, 2015 Jul-Sep. PMID 26430566, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detoxification of zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cation diffusion facilitator family protein 1;Zinc transporter 1
    NP_001300317.1
    • Confirmed by transcript evidence
    NP_509095.2
    • Confirmed by transcript evidence
    NP_509096.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6499916..6505133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076694.7 → NP_509095.2  Cation diffusion facilitator family protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18009, Q95QW4
      Conserved Domains (1) summary
      COG1230
      Location:93 → 510
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

    2. NM_001313388.6 → NP_001300317.1  Zinc transporter 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18009, Q95QW4
      UniProtKB/TrEMBL
      A0A0K3ASM2
      Conserved Domains (2) summary
      COG1230
      Location:61 → 478
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:73 → 185
      Cation_efflux; Cation efflux family

    3. NM_076695.6 → NP_509096.2  Cation diffusion facilitator family protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18009, Q95QW4
      Conserved Domains (1) summary
      COG1230
      Location:135 → 552
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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