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    rgs-2 RGS domain-containing protein;Regulator of G-protein signaling rgs-2 [ Caenorhabditis elegans ]

    Gene ID: 181414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgs-2
    Official Full Name
    RGS domain-containing protein;Regulator of G-protein signaling rgs-2
    Primary source
    WormBase:WBGene00004345
    Locus tag
    CELE_F16H9.1
    See related
    AllianceGenome:WB:WBGene00004345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Is expressed in head neurons; pharyngeal muscle cell; tail neurons; uterine muscle; and ventral cord neurons. Orthologous to several human genes including RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rgs-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (12712653..12728391)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Nuclear Hormone Receptor family Neighboring gene Nuclear Hormone Receptor family Neighboring gene Nuclear hormone receptor family member nhr-27 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P-GlycoProtein related Neighboring gene P-GlycoProtein related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Dusonchet J, et al. Hum Mol Genet, 2014 Sep 15. PMID 24794857, Free PMC Article
    2. Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Kang C, et al. Genes Dev, 2007 Sep 1. PMID 17785524, Free PMC Article
    3. Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep. Huang H, et al. G3 (Bethesda), 2017 Sep 7. PMID 28743807, Free PMC Article
    4. The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity. Krzyzanowski MC, et al. PLoS Genet, 2013. PMID 23874221, Free PMC Article
    5. G-protein signaling: satisfying the basic necessities of life. Wilkie TM. Curr Biol, 2000 Nov 30. PMID 11114530

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RGS domain-containing protein;Regulator of G-protein signaling rgs-2
    NP_001123134.1
    • Confirmed by transcript evidence
    NP_001257199.1
    • Confirmed by transcript evidence
    NP_001379248.1
    • Confirmed by transcript evidence
    NP_510124.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12712653..12728391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392863.1 → NP_001379248.1  RGS domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFV0
      Conserved Domains (1) summary
      cl02565
      Location:52 → 169
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_077723.6 → NP_510124.2  Regulator of G-protein signaling rgs-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510124.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49808
      Conserved Domains (1) summary
      cl02565
      Location:40 → 157
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. NM_001129662.4 → NP_001123134.1  RGS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123134.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECA3
      Conserved Domains (1) summary
      cl02565
      Location:33 → 150
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. NM_001270270.5 → NP_001257199.1  RGS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFC5
      Conserved Domains (1) summary
      cl02565
      Location:38 → 155
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49808.1

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