gpc-1 Guanine nucleotide-binding protein subunit gamma [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gpc-1
Official Full Name: Guanine nucleotide-binding protein subunit gamma
Primary source: WormBase:WBGene00001681
Locus tag: CELE_K02A4.2
See related: AllianceGenome:WB:WBGene00001681
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G-protein beta-subunit binding activity. Involved in sensory perception of taste. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in head mesodermal cell; intestine; and nervous system. Orthologous to several human genes including GNG7 (G protein subunit gamma 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gpc-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 2

Sequence:: Chromosome: X; NC_003284.9 (12881171..12882429, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPC-1 regulates olfactory adaptation in Caenorhabditis elegans, and acts upstream of egl-30.
Title: GPC-1, a G protein gamma-subunit, regulates olfactory adaptation in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02A4.2 (e-PCR)
- UniSTS:315947

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sensory perception of taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info
part_of heterotrimeric G-protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Guanine nucleotide-binding protein subunit gamma

NP_001379097.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12881171..12882429 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392864.1 → NP_001379097.1 Guanine nucleotide-binding protein subunit gamma [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P54406

Conserved Domains (1) summary

smart00224
Location:1 → 62

GGL; G protein gamma subunit-like motifs