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    Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 18173, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc11a1provided by MGI
    Official Full Name
    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1provided by MGI
    Primary source
    MGI:MGI:1345275
    See related
    Ensembl:ENSMUSG00000026177 AllianceGenome:MGI:1345275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bcg; Ity; Lsh; ity; Ity1; Nramp; Nramp1
    Summary
    Enables iron ion transmembrane transporter activity; manganese ion transmembrane transporter activity; and metal cation:proton antiporter activity. Involved in iron ion transport and manganese ion transport. Acts upstream of or within several processes, including defense response to other organism; intracellular monoatomic cation homeostasis; and regulation of gene expression. Located in late endosome membrane; lysosomal membrane; and phagocytic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including Buruli ulcer disease; autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 37.5), mammary gland adult (RPKM 13.7) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc11a1 in Genome Data Viewer
    Location:
    1 C3; 1 38.54 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74414318..74429974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74375014..74386057)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene paroxysmal nonkinesiogenic dyskinesia Neighboring gene STARR-positive B cell enhancer ABC_E3281 Neighboring gene STARR-positive B cell enhancer ABC_E4323 Neighboring gene STARR-seq mESC enhancer starr_01333 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:74433475-74433675 Neighboring gene ciliogenesis associated TTC17 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E2549 Neighboring gene STARR-seq mESC enhancer starr_01337 Neighboring gene predicted gene, 53562 Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene villin 1 Neighboring gene ubiquitin specific peptidase 37

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129156, MGC129157

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within L-arginine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within MHC class II biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell proliferation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within activation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of peptide antigen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cadmium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cadmium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification of cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular detoxification of cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within interleukin-3 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iron ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iron ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within macrophage activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in manganese ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in manganese ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within manganese ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in manganese ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metal ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nitrite transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T-helper 1 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of dendritic cell antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within respiratory burst IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within response to type II interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in phagocytic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in phagocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tertiary granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in tertiary granule membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    natural resistance-associated macrophage protein 1
    Names
    host resistance locus Bcg/Ity/Lsh
    solute carrier family 11 member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432094.1NP_001419023.1  natural resistance-associated macrophage protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC098570
    2. NM_013612.3NP_038640.2  natural resistance-associated macrophage protein 1 isoform 1

      See identical proteins and their annotated locations for NP_038640.2

      Status: VALIDATED

      Source sequence(s)
      AC098570
      Consensus CDS
      CCDS15047.1
      UniProtKB/Swiss-Prot
      P41251, Q3TB84
      UniProtKB/TrEMBL
      A0A087WNR0
      Related
      ENSMUSP00000027368.6, ENSMUST00000027368.6
      Conserved Domains (1) summary
      TIGR01197
      Location:53453
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74414318..74429974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162734.1XP_036018627.1  natural resistance-associated macrophage protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P41251, Q3TB84
      UniProtKB/TrEMBL
      A0A087WNR0
      Conserved Domains (1) summary
      TIGR01197
      Location:53453
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    2. XM_036162732.1XP_036018625.1  natural resistance-associated macrophage protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P41251, Q3TB84
      UniProtKB/TrEMBL
      A0A087WNR0
      Conserved Domains (1) summary
      TIGR01197
      Location:53453
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    3. XM_036162735.1XP_036018628.1  natural resistance-associated macrophage protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P41251, Q3TB84
      UniProtKB/TrEMBL
      A0A087WNR0
      Conserved Domains (1) summary
      TIGR01197
      Location:53453
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    4. XM_006495774.2XP_006495837.1  natural resistance-associated macrophage protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A087WNR0
      Conserved Domains (1) summary
      TIGR01197
      Location:1389
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters