Oc90 otoconin 90 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oc90provided by MGI
Official Full Name: otoconin 90provided by MGI
Primary source: MGI:MGI:1313269
See related: Ensembl:ENSMUSG00000015001 AllianceGenome:MGI:1313269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: oc95; PLA2L; Ocn-95; Pla2ll
Summary: Enables calcium ion binding activity and structural molecule activity. Involved in otolith mineralization. Located in extracellular matrix. Is expressed in several structures, including cerebellum external granule cell layer; inner ear; and retina nuclear layer. Orthologous to human OC90 (otoconin 90). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E14 (RPKM 5.4) and CNS E11.5 (RPKM 1.7) See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 29.16 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (65747899..65784260, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (65876050..65912411, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional cooperation between two otoconial proteins Oc90 and Nox3.
Title: Functional cooperation between two otoconial proteins Oc90 and Nox3.
Report otoconin 90 is attached to a scaffold consisting of the hexagonal fibrillar meshwork, characteristic of otolin, in the otoconia.
Title: Immunogold TEM of otoconin 90 and otolin - relevance to mineralization of otoconia, and pathogenesis of benign positional vertigo.
In vivo, the presence of Oc90 in wildtype (wt) mice leads to an enrichment of Ca2+ in the luminal matrices of the utricle and saccule, whereas absence of Oc90 in the null mice leads to drastically reduced matrix-Ca2+.
Title: Matrix recruitment and calcium sequestration for spatial specific otoconia development.
Otolin 1 interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1 in the inner ear.
Title: Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.
OC90 is a multifunctional molecule which facilitates calcite nucleation, inhibits crystal growth and induces changes in crystal morphology, which result in a shape characteristic of native otoconia.
Title: In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure.
Otoconin-90 deletion in knockout mice leads to vestibular apparatus abnormalities and impairment of balance.
Title: Otoconin-90 deletion leads to imbalance but normal hearing: a comparison with other otoconia mutants.
Results show normal inner ear epithelial morphology but reduced acellular matrices, including otoconial, cupular and tectorial membranes, in Oc90 null mice, likely due to an absence of Oc90 and a profound reduction of otolin.
Title: Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrix.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Radiation induced (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548365

AI894211 (e-PCR)
- UniSTS:165934

PMC15170P1 (e-PCR)
- UniSTS:271166

AW822089 (e-PCR)
- UniSTS:209092

Oc90 (e-PCR), detects polymorphism
- UniSTS:144076

PMC15170P2 (e-PCR)
- UniSTS:144077

NoName (e-PCR)
- UniSTS:237309

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in otolith mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: otoconin-90

Names: otoconin-95; phospholipase A2-like like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347038.2 → NP_001333967.1 otoconin-90 isoform 2

Status: VALIDATED

Source sequence(s)

AC091276

Consensus CDS

CCDS84171.1

UniProtKB/TrEMBL

F6T2M1, Q80ZM2

Related

ENSMUSP00000078709.8, ENSMUST00000079776.14
NM_001411454.1 → NP_001398383.1 otoconin-90 isoform 3

Status: VALIDATED

Source sequence(s)

AC091276

UniProtKB/TrEMBL

F6T2M1
NM_001411455.1 → NP_001398384.1 otoconin-90 isoform 4

Status: VALIDATED

Source sequence(s)

AC091276

UniProtKB/TrEMBL

F6T2M1
NM_010953.3 → NP_035083.1 otoconin-90 isoform 1 precursor

See identical proteins and their annotated locations for NP_035083.1

Status: VALIDATED

Source sequence(s)

AC091276

Consensus CDS

CCDS27508.1

UniProtKB/Swiss-Prot

Q9CZ60, Q9Z0L3, Q9Z225

UniProtKB/TrEMBL

F6T2M1

Related

ENSMUSP00000062865.5, ENSMUST00000060522.11

Conserved Domains (1) summary

cd04707
Location:317 → 432

otoconin_90; otoconin_90: Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

65747899..65784260 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245489.1 → XP_011243791.1 otoconin-90 isoform X2

UniProtKB/TrEMBL

F6T2M1

Related

ENSMUSP00000121227.2, ENSMUST00000156996.8

Conserved Domains (1) summary

cd04707
Location:302 → 417

otoconin_90; Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The PLA2-like ...
XM_011245488.1 → XP_011243790.1 otoconin-90 isoform X1

UniProtKB/TrEMBL

F6T2M1

Conserved Domains (1) summary

cd04707
Location:318 → 433

otoconin_90; Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The PLA2-like ...
XM_011245492.2 → XP_011243794.1 otoconin-90 isoform X5

UniProtKB/TrEMBL

F6ZCJ0

Related

ENSMUSP00000114254.2, ENSMUST00000135442.8

Conserved Domains (2) summary

cd04707
Location:190 → 305

otoconin_90; Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The PLA2-like ...

cl05417
Location:1 → 66

PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
XM_011245494.1 → XP_011243796.1 otoconin-90 isoform X7

Conserved Domains (1) summary

cd04707
Location:109 → 224

otoconin_90; Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The PLA2-like ...
XM_011245493.1 → XP_011243795.1 otoconin-90 isoform X6

Conserved Domains (1) summary

cd04707
Location:125 → 240

otoconin_90; Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The PLA2-like ...